Performance evaluation of urine osmolality measurement on Sysmex UF-5000 and the effect of molecules and particles in urine

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dc.authorid0000-0002-7006-3125en_US
dc.authorid0000-0003-0434-3206en_US
dc.authorid0000-0002-4060-3354en_US
dc.contributor.authorYis, Özgür Mehmet
dc.contributor.authorAlışık, Murat
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorSert, Mehmet A.
dc.contributor.authorErdoğan, Utku G.
dc.contributor.authorAteş, Merve
dc.date.accessioned2023-11-10T11:31:19Z
dc.date.available2023-11-10T11:31:19Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Urine osmolality determines the concentration ability of the kidney. Therefore, it is used to assess the body's hydration status, electrolyte levels, and acid-base disturbances. We aimed to evaluate the analytical perfor-mance of osmolality measurement of the Sysmex UF-5000 (UF-5000), to examine the effect of different molecules and particles in the urine on the osmolality measurement. Methods: Complete urinalysis and conductivity-based osmolality analysis with UF-5000 and osmolality analysis with Advanced (R) Model 3320 Micro-Osmometer (AI-3320) by freezing point reduction method were performed in the urine samples. Samples were grouped as negative, glucosuria, proteinuria, hematuria, pyuria, crystalluria, and urobilinogen.Results: Total impressions were calculated as < 5% and accuracy values were < 1.66% in both analyzers. The re-gression equation was found to be y =-12.54 + 0.956x and the relative difference between the analyzers was 8.7% in 586 samples. When patients with Glucose > 2+ were excluded the regression equation of 507 samples was found as y = 5.10 + 0.948x and the relative difference was 4.6%. The percentages of samples with a difference greater than the allowable difference were 18.8%, 11.6%, 35.9%, 13.7%, 18.7%, and < 12.2% in all samples, all samples without glucosuria > 2+, glucosuria, glucosuria < 3+, proteinuria, and other subgroups, respectively. Conclusions: Considering the good accessibility of the automated routine complete urine analyzer, UF-5000 can be considered to determine whether urine osmolality is within reference or should be measured by methods based on colligative properties. Thus, referral of patients to a clinic that uses the colligative measurement method may be used more effectively.(Clin. Lab. 2023;69:543-552. DOI: 10.7754/Clin.Lab.2022.220536)en_US
dc.identifier.citationYis, O. M., Alisik, M., Bugdayci, G., Sert, M. A., Erdogan, U. G., & Ates, M. (2023). Performance Evaluation of Urine Osmolality Measurement on Sysmex UF-5000 and the Effect of Molecules and Particles in Urine. Clinical Laboratory, 69(3).en_US
dc.identifier.endpage552en_US
dc.identifier.issn1433-6510
dc.identifier.issue3en_US
dc.identifier.pmid36912295en_US
dc.identifier.scopus2-s2.0-85150225765en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage543en_US
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000958288400012
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11824
dc.identifier.volume69en_US
dc.identifier.wosWOS:000958288400012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYis, Özgür Mehmet
dc.institutionauthorAlışık, Murat
dc.institutionauthorBuğdaycı, Güler
dc.language.isoenen_US
dc.publisherClinical Laboratory Publishingen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUrine Osmolalityen_US
dc.subjectConductivityen_US
dc.subjectUrineen_US
dc.subjectFreezing Point Depressionen_US
dc.titlePerformance evaluation of urine osmolality measurement on Sysmex UF-5000 and the effect of molecules and particles in urineen_US
dc.typeArticleen_US

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