Controversy and consensus on indications for sperm DNA fragmentation testing in male infertility: A global survey, current guidelines, and expert recommendations

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dc.authorid0000-0003-0585-1026en_US
dc.authorid0000-0002-0362-9109en_US
dc.authorid0000-0003-0503-3533en_US
dc.authorid0000-0002-8070-4088en_US
dc.authorid0000-0002-8902-517Xen_US
dc.contributor.authorAgarwal, Ashok
dc.contributor.authorFarkouh, Ala'a
dc.contributor.authorSaleh, Ramadan
dc.contributor.authorHamoda, Taha Abo-Almagd Abdel-Meguid
dc.contributor.authorHarraz, Ahmed M.
dc.contributor.authorSöğütdelen, Emrullah
dc.date.accessioned2023-09-08T11:33:56Z
dc.date.available2023-09-08T11:33:56Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: Sperm DNA fragmentation (SDF) testing was recently added to the sixth edition of the World Health Organization laboratory manual for the examination and processing of human semen. Many conditions and risk factors have been associ-ated with elevated SDF; therefore, it is important to identify the population of infertile men who might benefit from this test. The purpose of this study was to investigate global practices related to indications for SDF testing, compare the relevant pro-fessional society guideline recommendations, and provide expert recommendations. Materials and Methods: Clinicians managing male infertility were invited to take part in a global online survey on SDF clini-cal practices. This was conducted following the CHERRIES checklist criteria. The responses were compared to professional society guideline recommendations related to SDF and the appropriate available evidence. Expert recommendations on indi-cations for SDF testing were then formulated, and the Delphi method was used to reach consensus. Results: The survey was completed by 436 experts from 55 countries. Almost 75% of respondents test for SDF in all or some men with unexplained or idiopathic infertility, 39% order it routinely in the work-up of recurrent pregnancy loss (RPL), and 62.2% investigate SDF in smokers. While 47% of reproductive urologists test SDF to support the decision for varicocele repair surgery when conventional semen parameters are normal, significantly fewer general urologists (23%; p=0.008) do the same. Nearly 70% would assess SDF before assisted reproductive technologies (ART), either always or for certain conditions. Recur-rent ART failure is a common indication for SDF testing. Very few society recommendations were found regarding SDF testing. Conclusions: This article presents the largest global survey on the indications for SDF testing in infertile men, and demon-strates diverse practices. Furthermore, it highlights the paucity of professional society guideline recommendations. Expert recommendations are proposed to help guide clinicians.en_US
dc.identifier.citationAgarwal, A., Farkouh, A. A., Saleh, R., Hamoda, T. A. A. A. M., Harraz, A. M., Kavoussi, P., ... & Forum, G. A. (2023). Controversy and consensus on indications for sperm DNA fragmentation testing in male infertility: A global survey, current guidelines, and expert recommendations. The World Journal of Men's Health, 41(3), 575.en_US
dc.identifier.doi10.5534/wjmh.220282
dc.identifier.endpage28en_US
dc.identifier.issn2287-4208
dc.identifier.issn2287-4690
dc.identifier.pmid37118960en_US
dc.identifier.scopus2-s2.0-85159180302en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.5534/wjmh.220282
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11685
dc.identifier.wosWOS:000991988300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSöğütdelen, Emrullah
dc.language.isoenen_US
dc.publisherKorean Society for Sexual Medicine and Andrologyen_US
dc.relation.ispartofWorld Journal of Mens Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDelphi Methoden_US
dc.subjectDNA Fragmentationen_US
dc.subjectMale Infertilityen_US
dc.subjectDeoxyribonucleic-Acid Fragmentationen_US
dc.subjectOxidative Stressen_US
dc.subjectEuropean Associationen_US
dc.titleControversy and consensus on indications for sperm DNA fragmentation testing in male infertility: A global survey, current guidelines, and expert recommendationsen_US
dc.typeArticleen_US

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