Evaluation of the effects of quercetin on the rewarding property of ethanol in mice

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dc.authorid0000-0003-1075-9574en_US
dc.contributor.authorYunusoğlu, Oruç
dc.date.accessioned2023-05-25T07:24:09Z
dc.date.available2023-05-25T07:24:09Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: The flavonoid quercetin has several pharmacological effects on the nervous system. Previous research showed that quercetin has useful influences on some mechanisms that are relevant in drug and substance addiction. Alcohol addiction, also known as alcoholism, is a disorder that influences the population in all walks of life. The purpose of the current study was to investigate whether quercetin affects the acquisition, extinction, and reinstatement of ethanol-induced conditioned place preference (ethanol-CPP) in adolescent mice. Methods: CPP was established by administration of intraperitoneal (i.p.) ethanol (2.0 g/kg) in a conditioning trial. The mice were pretreated with quercetin (at doses of 10, 30, and 100 mg/kg, i.p.) 30 minutes before each ethanol injection to test the effects of quercetin on the reward properties of ethanol. Ethanol-CPP was extinguished (13days) by repeated testing, during which conditioned mice were given different doses of quercetin every day. Lastly, efficacy of quercetin in preventing reinstatement of ethanol-CPP triggers was also assessed by the administration of single dose ethanol (0.4 g/kg, i.p.). Results: Quercetin pretreatment attenuated the acquisition and reinstatement. In addition, quercetin administration accelerated the extinction of ethanol-CPP. Conclusions: In conclusion, these results may cast a novel light on quercetin as an agent that could be potentially useful to attenuate different effects of ethanol and as adjuvant pharmacotherapy for ethanol addiction. However, future studies are needed to demonstrate the detailed underlying mechanisms of quercetin on ethanol addiction.en_US
dc.identifier.citationYunusoğlu, O. (2022). Evaluation of the effects of quercetin on the rewarding property of ethanol in mice. Neuroscience Letters, 768, 136383.en_US
dc.identifier.doi10.1016/j.neulet.2021.136383
dc.identifier.endpage7en_US
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.pmid34864087en_US
dc.identifier.scopus2-s2.0-85120736044en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.neulet.2021.136383
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10951
dc.identifier.volume768en_US
dc.identifier.wosWOS:000733667700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYunusoğlu, Oruç
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectQuercetinen_US
dc.subjectEthanolen_US
dc.subjectAddictionen_US
dc.subjectConditioned Place Preferenceen_US
dc.subjectMiceen_US
dc.titleEvaluation of the effects of quercetin on the rewarding property of ethanol in miceen_US
dc.typeArticleen_US

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