Portraying infective endocarditis: Results of multinational ID-IRI study

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dc.authorid0000-0002-0621-4865
dc.authorid0000-0002-4713-9478
dc.authorid0000-0002-0622-6823
dc.authorid0000-0001-6956-3838
dc.authorid0000-0003-0442-5981
dc.contributor.authorErdem, Hakan
dc.contributor.authorPuca, Edmond
dc.contributor.authorRuch, Yvon
dc.contributor.authorSantos, Lurdes
dc.contributor.authorGhanem-Zoubi, Nesrin
dc.contributor.authorSırmatel, Fatma
dc.date.accessioned2021-06-23T19:51:03Z
dc.date.available2021-06-23T19:51:03Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractInfective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).en_US
dc.identifier.doi10.1007/s10096-019-03607-x
dc.identifier.endpage1763en_US
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.issue9en_US
dc.identifier.pmid31187307en_US
dc.identifier.scopus2-s2.0-85067399544en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1753en_US
dc.identifier.urihttps://doi.org/10.1007/s10096-019-03607-x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9914
dc.identifier.volume38en_US
dc.identifier.wosWOS:000481757500021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSırmatel, Fatma
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal Of Clinical Microbiology & Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInfective Endocarditisen_US
dc.subjectProstheticen_US
dc.subjectNativeen_US
dc.subjectS. Aureusen_US
dc.subjectBlood Cultureen_US
dc.titlePortraying infective endocarditis: Results of multinational ID-IRI studyen_US
dc.typeArticleen_US

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