Shared fate of meningeal mast cells and sensory neurons in migraine

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dc.authorid0000-0002-3277-5535en_US
dc.authorid0000-0001-9261-2634en_US
dc.authorid0000-0001-5912-9392
dc.contributor.authorIrmak, Duygu Koyuncu
dc.contributor.authorKılınç, Erkan
dc.contributor.authorTöre, Fatma
dc.date.accessioned2021-06-23T19:51:50Z
dc.date.available2021-06-23T19:51:50Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractMigraine is a primary headache disorder which has complex neurogenic pathophysiological mechanisms still requiring full elucidation. The sensory nerves and meningeal mast cell couplings in the migraine target tissue are very effective interfaces between the central nervous system and the immune system. These couplings fall into three categories: intimacy, cross-talk and a shared fate. Acting as the immediate call-center of the neuroimmune system, mast cells play fundamental roles in migraine pathophysiology. Considerable evidence shows that neuroinflammation in the meninges is the key element resulting in the sensitization of trigeminal nociceptors. The successive events such as neuropeptide release, vasodilation, plasma protein extravasation, and mast cell degranulation that form the basic characteristics of the inflammation are believed to occur in this persistent pain state. In this regard, mast cells and sensory neurons represent both the target and source of the neuropeptides that play autocrine, paracrine, and neuro-endocrine roles during this inflammatory process. This review intends to contribute to a better understanding of the meningeal mast cell and sensory neuron bi-directional interactions from molecular, cellular, functional points of view. Considering the fact that mast cells play a sine qua non role in expanding the opportunities for targeted new migraine therapies, it is of crucial importance to explore these multi-faceted interactions.en_US
dc.identifier.doi10.3389/fncel.2019.00136
dc.identifier.issn1662-5102
dc.identifier.pmid31024263en_US
dc.identifier.scopus2-s2.0-85064204955en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fncel.2019.00136
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10055
dc.identifier.volume13en_US
dc.identifier.wosWOS:000463651300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKılınç, Erkan
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Cellular Neuroscienceen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMigraineen_US
dc.subjectNeuroinflammationen_US
dc.subjectMast Cellsen_US
dc.subjectSensory Neuronsen_US
dc.subjectATPen_US
dc.subjectCGRPen_US
dc.subjectPACAPen_US
dc.subjectAutonomic Nervous Systemen_US
dc.titleShared fate of meningeal mast cells and sensory neurons in migraineen_US
dc.typeReview Articleen_US

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