Tear organic acid analysis after corneal collagen crosslinking in keratoconus

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dc.authorid0000-0002-3053-2396
dc.contributor.authorSağlık, Ayhan
dc.contributor.authorKoyuncu, İsmail
dc.contributor.authorSoydan, Adem
dc.contributor.authorSağlık, Ferdağ
dc.contributor.authorGönel, Ataman
dc.date.accessioned2021-06-23T19:54:27Z
dc.date.available2021-06-23T19:54:27Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: This study examined changes in the levels of organic acids, which are important tear metabolites, after corneal collagen crosslinking (CXL) treatment for keratoconus. Methods: This prospective, nonrandomized, interventional case series included a single eye from 24 patients who were scheduled to receive CXL treatment (Dresden protocol) for progressive keratoconus. Before CXL treatment and at 6 months after treatment, tears were collected in capillary tubes. The patients were separated into four groups as males, females, and ages 18 years younger and >18 older. The organic acid profiles of the tear samples were analyzed using mass spectrometry. Results: An evaluation was made of 12 females and 12 males with a mean age of 19.20 +/- 4.06 years (range: 12-27 years). The greatest percentage increase in organic acids after CXL treatment was observed for N-acetyl-L-aspartic acid (66% increase). The organic acid showing the greatest decrease was 3-OH butyric acid (61% decrease). A decrease of 46% was found (P=0.263) in the lactic acid/malic acid ratio. Conclusion: Metabolomic studies of tears could facilitate a new and objective process in the follow-up period or in the determination of prognosis after CXL treatment for diseases such as keratoconus, which has a multifactorial etiology.en_US
dc.identifier.doi10.1097/ICL.0000000000000644
dc.identifier.endpageS128en_US
dc.identifier.issn1542-2321
dc.identifier.issn1542-233X
dc.identifier.pmid31425352en_US
dc.identifier.scopus2-s2.0-85081942150en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageS122en_US
dc.identifier.urihttps://doi.org/10.1097/ICL.0000000000000644
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10549
dc.identifier.volume46en_US
dc.identifier.wosWOS:000570962600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSoydan, Adem
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEye & Contact Lens-Science And Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOrganic Acidsen_US
dc.subjectMetabolomicsen_US
dc.subjectKeratoconusen_US
dc.subjectCrosslinkingen_US
dc.subjectTears Metabolitesen_US
dc.titleTear organic acid analysis after corneal collagen crosslinking in keratoconusen_US
dc.typeArticleen_US

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