Protective effect of octreotide on intra-tracheal bleomycin-induced oxidative damage in rats

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dc.contributor.authorKara, Haki
dc.contributor.authorKarataş, Fikret
dc.contributor.authorTuğ, Tuncer
dc.contributor.authorCanatan, Halit
dc.contributor.authorKaraoğlu, Aziz
dc.date.accessioned2021-06-23T19:27:01Z
dc.date.available2021-06-23T19:27:01Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe present study is aimed at determining the effect of parenteral octreotide against oxidative damage caused by intra-tracheal bleomycin (BLM) administration. A total of 30 male Wistar rats randomly divided into three groups (control, bleomycin alone, and bleomycin and octreotide) were used in the study. A group of animals received a single dose of intra-tracheal bleomycin (7.5 mg/kg). Animals in another group, which also received intra-tracheal bleomycin, were given 82.5 mu g/kg octreotide via i.m. injection for a week. Animals in the control group received neither bleomycin nor octreotide. All animals were sacrificed at the end of the experiment. Serum levels of malondialdehyde, vitamins A, E, and C, selenium levels were determined. In addition, glutathion peroxidase activity levels in erythrocytes were also determined. Malondialdehyde levels and glutathion peroxidase activity were increased whereas antioxidant vitamin levels were decreased significantly in animals that received only bleomycin compared to control animals (p<0.05). The values in rats that received bleomycin and octreotide were found to be closer to the control group (p<0.05). Selenium levels in animals that received only bleomycin were determined to be reduced compared to controls (p<0.05). On the other hand, selenium levels in bleomycin and octreotide groups were similar to control values in (p<0.05). In conclusion, bleomycin induces a severe stress and more importantly increases the amount of free radicals whereas octreotide administration reduces this oxidative damage significantly. (C) 2009 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.etp.2009.03.012
dc.identifier.endpage241en_US
dc.identifier.issn0940-2993
dc.identifier.issn1618-1433
dc.identifier.issue3en_US
dc.identifier.pmid19427178en_US
dc.identifier.scopus2-s2.0-77952890083en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage235en_US
dc.identifier.urihttps://doi.org/10.1016/j.etp.2009.03.012
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6714
dc.identifier.volume62en_US
dc.identifier.wosWOS:000279000200004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTuğ, Tuncer
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofExperimental And Toxicologic Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOctreotideen_US
dc.subjectBleomycinen_US
dc.subjectAntioxidant Vitaminsen_US
dc.subjectSeleniumen_US
dc.subjectMolondialdehydeen_US
dc.subjectGSH-Pxen_US
dc.titleProtective effect of octreotide on intra-tracheal bleomycin-induced oxidative damage in ratsen_US
dc.typeArticleen_US

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