The use of del nido cardioplegia for myocardial protection in isolated coronary artery bypass surgery

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dc.authorid0000-0002-9938-8599
dc.contributor.authorÇayır, Mustafa Cağdaş
dc.contributor.authorYüksel, Ahmet
dc.date.accessioned2021-06-23T19:54:37Z
dc.date.available2021-06-23T19:54:37Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground The del Nido (DN) cardioplegia solution has been widely used in paediatric open-heart surgery for years; however, its application in adult open-heart surgery has not yet gained sufficient popularity. We investigated the safety and efficiency of the DN cardioplegia solution versus the traditional crystalloid cardioplegia solution [St. Thomas' Hospital (STH) cardioplegia solution] in adult patients undergoing coronary artery bypass grafting (CABG). Methods A retrospective comparative analysis of 200 consecutive patients undergoing isolated on-pump CABG between April 2016 and September 2017 was performed. Patients were divided into two groups: DN group (n = 100) and STH group (n = 100). Groups were compared with regard to perioperative clinical outcomes, and the safety and efficiency of the DN cardioplegia solution in CABG surgery were evaluated. Results In the DN group, mean aortic cross-damp, cardiopulmonary bypass, and total operation times were significantly shorter than in the STH group. After the release of the aortic cross-clamp, the requirement for intraoperative defibrillation was significantly less in the DN group. There were no significant differences between the groups in terms of the levels of perioperative cardiac biomarkers (including creatine kinasemyocardial band and troponin I), major postoperative adverse events, and in-hospital mortality. Conclusions This study revealed that the use of the DN cardioplegia solution in adult patients undergoing isolated CABG provides significantly shorter aortic cross-clamp, cardiopulmonary bypass, and total operation times compared with the traditional cardioplegias solution. The DN solution could be used as a safe and efficient alternative to the traditional cardioplegia solutions in CABG surgery.en_US
dc.identifier.doi10.1016/j.hlc.2018.12.006
dc.identifier.endpage307en_US
dc.identifier.issn1443-9506
dc.identifier.issn1444-2892
dc.identifier.issue2en_US
dc.identifier.pmid30723044en_US
dc.identifier.scopus2-s2.0-85060865507en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage301en_US
dc.identifier.urihttps://doi.org/10.1016/j.hlc.2018.12.006
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10599
dc.identifier.volume29en_US
dc.identifier.wosWOS:000506901000019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYüksel, Ahmet
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofHeart Lung And Circulationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDel Nido cardioplegiaen_US
dc.subjectCoronary Artery Bypass Graftingen_US
dc.subjectMyocardial Protectionen_US
dc.titleThe use of del nido cardioplegia for myocardial protection in isolated coronary artery bypass surgeryen_US
dc.typeArticleen_US

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