Predictors of abdominal obesity and high susceptibility of cardiometabolic risk to its increments among Turkish women: a prospective population-based study

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dc.authorid0000-0001-7571-7039en_US
dc.authorid0000-0001-5815-6700
dc.authorid0000-0001-7571-7039
dc.contributor.authorOnat, Altan
dc.contributor.authorSarı, İbrahim
dc.contributor.authorHergenç, Gülay
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorUyarel, Hüseyin
dc.contributor.authorCan, Günay
dc.contributor.authorŞansoy, Vedat
dc.date.accessioned2021-06-23T19:20:26Z
dc.date.available2021-06-23T19:20:26Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractTo investigate determinants of abdominal obesity and its metabolic and clinical consequences relative to its degree in women, a prospective evaluation of 1682 female participants (aged 28-79 years at baseline), representative of Turkey's women, was performed. For components of metabolic syndrome (MS), criteria of National Cholesterol Education Program guidelines were adopted, modified for cut point of 91 cm or greater for abdominal obesity and less than 45 mg/dL for low high-density lipoprotein (HDL) cholesterol. Fasting insulin and C-reactive protein concentrations and (inversely) smoking more than 10 cigarettes daily were significant predictors of newly developed abdominal obesity at a follow-up of mean 5.9 years. In the prediction of high triglyceride-low HDL dyslipidemia, elevated blood pressure (BP) or MS and doubling of baseline fasting insulin level contributed approximately 25% to the hazard ratio (HR), whereas waist circumference exhibited independent HRs of 1.30, 1.62, and 2.22, respectively. Waist girth (or body mass index) quartiles was the major predictor (HR, 1.72) of diabetes mellitus (DM), followed by physical inactivity and total cholesterol and insulin levels, all independent of each other. Waist girth quartiles in women conferred excess risk of incident coronary heart disease from quartile II onward, independent of age, DM, and elevated BP. Fasting insulin and C-reactive protein levels and (inversely) heavy smoking are main predictors in Turkish women of abdominal obesity. Across waist girth quartiles, multiadjusted relative risks for dyslipidemia, elevated BP, MS, and coronary heart disease rise sharply and asymptotically from quartile II (>= 83 cm) onward, whereas risk of DM emerges in the top quartile. A waist girth of 83 cm or greater should be regarded as abdominal obesity among Turkish women. (c) 2007 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.metabol.2006.10.016
dc.identifier.endpage356en_US
dc.identifier.issn0026-0495
dc.identifier.issn1532-8600
dc.identifier.issue3en_US
dc.identifier.pmid17292723en_US
dc.identifier.scopus2-s2.0-33846785300en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage348en_US
dc.identifier.urihttps://doi.org/10.1016/j.metabol.2006.10.016
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6113
dc.identifier.volume56en_US
dc.identifier.wosWOS:000244421900009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYazıcı, Mehmet
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofMetabolism-Clinical And Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiometabolic risken_US
dc.titlePredictors of abdominal obesity and high susceptibility of cardiometabolic risk to its increments among Turkish women: a prospective population-based studyen_US
dc.typeArticleen_US

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