Nasal pepsin assay and ph monitoring in chronic rhinosinusitis

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dc.authorid0000-0002-1466-5746en_US
dc.authorid0000-0002-9698-0546en_US
dc.contributor.authorÖzmen, Süay
dc.contributor.authorYücel, Ömer Taşkın
dc.contributor.authorSinici, İncilay
dc.contributor.authorÖzmen, Ömer Afşin
dc.contributor.authorSüslü, Ahmet Emre
dc.date.accessioned2021-06-23T19:25:51Z
dc.date.available2021-06-23T19:25:51Z
dc.date.issued2008
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives/Hypothesis: The primary objective of this study was to determine the relationship between chronic rhinosinusitis (CRS) and laryngopharyngeal reflux (LPR). We also investigated the diagnostic value of pepsin in nasal lavage by means of fluorometric assay as compared with 24-hour dual-probe pH monitoring. Study Design and Methods: This is a controlled, prospective study from a retrospective dataset of 33 patients recruited for endoscopic sinus surgery between 2005 and 2006 in a tertiary care referral center (Hacettepe University Medical Center). All patients underwent 24-hour dual-probe pH monitoring and nasal lavage fluid investigation for pepsin. A fluorometric pepsin assay using casein-fluorescein isothiocyanate in nasal lavage fluid was used to detect LPR. The control group included 20 patients who were proven not to have sinusitis. Results: A higher incidence of pharyngeal acid reflux events was found in patients with CRS (29 of 33, 88%) compared with the control patients (11 of 20, 55%). The difference was statistically significant (P = .01). The fluorometric pepsin assay was correlated. to the results of 24-hour dual-probe monitoring for LPR diagnosis with a 100% sensitivity and 92.5% specificity. These data suggest that an association between CRS and LPR is present and that the detection of pepsin in nasal lavage fluid may provide a noninvasive and feasible method of LPR screening.en_US
dc.identifier.doi10.1097/MLG.0b013e318165e324
dc.identifier.endpage894en_US
dc.identifier.issn0023-852X
dc.identifier.issn1531-4995
dc.identifier.issue5en_US
dc.identifier.pmid18520187en_US
dc.identifier.scopus2-s2.0-43049085914en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage890en_US
dc.identifier.urihttps://doi.org/10.1097/MLG.0b013e318165e324
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6288
dc.identifier.volume118en_US
dc.identifier.wosWOS:000260662100023en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSüslü, Ahmet Emre
dc.language.isoenen_US
dc.publisherJohn Wiley & Sonsen_US
dc.relation.ispartofThe Laryngoscopeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic Rhinosinusitisen_US
dc.subjectNasal Lavageen_US
dc.subjectPepsin Assayen_US
dc.titleNasal pepsin assay and ph monitoring in chronic rhinosinusitisen_US
dc.typeArticleen_US

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