Fibrinogen-A? THR312ALA polymorphism is associated to chronic thromboembolic pulmonary hypertension in Turkey

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dc.authorid0000-0002-6923-736Xen_US
dc.authorid0000-0002-1316-4552en_US
dc.authorid0000-0002-9234-1560en_US
dc.authorid0000-0003-4791-8946en_US
dc.authorid0000-0002-6049-7229en_US
dc.authorid0000-0002-0891-0020en_US
dc.contributor.authorÇörtük, Mustafa
dc.contributor.authorYıldızeli, Bedrettin
dc.contributor.authorKurar, Ercan
dc.contributor.authorKayış, Seyit Ali
dc.contributor.authorTanrıverdi, Elif
dc.contributor.authorÇetinkaya, Erdoğan
dc.date.accessioned2023-07-28T12:22:44Z
dc.date.available2023-07-28T12:22:44Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionThis study was supported by Karabuek University, Coordinatorship of Research Projects (KBUEBAP-17-KP-073).en_US
dc.description.abstractBackground: Chronic thromboembolic pulmonary hypertension is a condition that occurs after mechanical obstruction of the pulmonary arteries by thrombus. Since the frequency and demographics of chronic thromboembolic pulmonary hypertension differ between countries, it is thought that genetic factors may play a role in its development. The aim of this study is to reveal the status of VKORC1, CYP2C9*3, CYP2C9*7, and fibrinogen-A alpha THR312ALA gene polymorphisms in chronic thromboembolic pulmonary hypertension patients in Turkey.Methods: In this prospective cross-sectional study, a total of 46 chronic thromboembolic pulmonary hypertension patients and 106 healthy volunteers were included. Polymerase chain reaction-restriction fragment length polymorphism method was used to determine candidate gene polymorphisms for chronic thromboembolic pulmonary hypertension. The general population parameters of each locus were calculated, and the relationship between dominant, co-dominant, and recessive genotype models and chronic thrombo-embolic pulmonary hypertension was analyzed.Results: For the fibrinogen-A alpha gene, those with the THR/THR genotype were found to have a 13.51 (95% CI: 2.688-33.333) times less susceptibility rate to the disease than those with the ALA/ THR genotype, the susceptibility of THR/ALA genotype to the disease was 5.026 (95% CI: 1.774-14.242) times more than those with ALA/ALA genotype. There was no difference between patient groups for VKORC1, CYP2C9*3 genes (P > .05). Since the CYP2C9*7 patient group was monomorphic for the ILE allele, the patient/control odds ratio and 95% CI could not be calculated.Conclusion: This study shows that there is an association between the fibrinogen-A alpha gene ALA polymorphism at the amino acid position of 312 and the development of chronic thromboembolic pulmonary hypertension, but not between the CYP2C9 and VKORC1 gene polymorphisms.en_US
dc.description.sponsorshipKarabuek University, Coordinatorship of Research Project [KB?BAP-17-KP-073]en_US
dc.identifier.citationÇörtük, M., Yıldızeli, B., Kurar, E., Kayış, S. A., Tanrıverdi, E., & Çetinkaya, E. (2023). Fibrinogen-Aα THR312ALA Polymorphism is Associated to Chronic Thromboembolic Pulmonary Hypertension in Turkey. Anatolian Journal of Cardiology, 27(3), 153.en_US
dc.identifier.doi10.14744/AnatolJCardiol.2022.2392
dc.identifier.endpage159en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue3en_US
dc.identifier.pmid36856592en_US
dc.identifier.scopus2-s2.0-85149427201en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage153en_US
dc.identifier.trdizinid1168729en_US
dc.identifier.urihttp://dx.doi.org/10.14744/AnatolJCardiol.2022.2392
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11396
dc.identifier.volume27en_US
dc.identifier.wosWOS:000954450700007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKayış, Seyit Ali
dc.language.isoenen_US
dc.publisherKare Publishingen_US
dc.relation.ispartofAnatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic Thromboembolic Pulmonary Hypertensionen_US
dc.subjectPulmonary Arterial Hyper-Tensionen_US
dc.subjectAnticoagulantsen_US
dc.subjectGenetic Polymorphismen_US
dc.subjectFibrinogen Alphaen_US
dc.subjectRFLPen_US
dc.titleFibrinogen-A? THR312ALA polymorphism is associated to chronic thromboembolic pulmonary hypertension in Turkeyen_US
dc.typeArticleen_US

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