Clinical outcomes and prognostic factors of adult's Ewing sarcoma family of tumors: single center experience

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dc.authorid0000-0002-6839-2632
dc.authorid0000-0002-8394-8168
dc.authorid0000-0002-6291-7573
dc.authorid0000-0002-6665-9000
dc.contributor.authorÜyetürk, Ümmügül
dc.contributor.authorHelvacı, Kaan
dc.contributor.authorDemirci, Ayşe
dc.contributor.authorSönmez, Özlem Uysal
dc.contributor.authorTürker, İbrahim
dc.date.accessioned2021-06-23T19:44:54Z
dc.date.available2021-06-23T19:44:54Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim of the study was to investigate the demographics of Ewing sarcoma family of tumours (ESTF) patients, treatment alternatives, clinical outcomes, and prognostic factors for survival. Material and methods: We retrospectively reviewed 39 patients with ESFT who were admitted to our institute between September 2008 and September 2012. Results: The patients included 32 (82.1%) males and seven (17.9%) females of median age 24 (range, 18-66) years. Among the 27 patients with a primary osseous localization, 17 (43.5%) had a central axis localization. Fifteen patients (38.5%) had metastases at the time of diagnosis. Patients were followed up for a median period of 18 (range, 2-134) months. The median event-free survival (EFS) was 23 (range, 1-64) months, and the 1- and 4-year EFS were 60% and 48%, respectively. The median overall survival (OS) was 91 (range, 1-188) months, and the 1- and 4-year OS were 78% and 54%, respectively. Gender, age, primary tumor site, and local treatment modalities, either alone or in combination, did not have a significant effect on OS (p = 0.210, p = 0.617, p = 0.644, and p = 0.417, respectively). In contrast, osseous site of peripheral localization, limited stage, and metastasis to the bone significantly affected OS (p = 0.015, p < 0.001, and p = 0.042, respectively). Conclusions: ESFTs are aggressive tumors with a high rate of relapse and metastatic potential. Patients with peripheral bone involvement and limited stage had a good prognosis. Appropriate surgical resection, radiotherapy, and aggressive chemotherapy regimens are recommended.en_US
dc.identifier.doi10.5114/wo.2016.58487
dc.identifier.endpage146en_US
dc.identifier.issn1428-2526
dc.identifier.issn1897-4309
dc.identifier.issue2en_US
dc.identifier.pmid27358593en_US
dc.identifier.scopus2-s2.0-85002125673en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://doi.org/10.5114/wo.2016.58487
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9067
dc.identifier.volume20en_US
dc.identifier.wosWOS:000382525900008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜyetürk, Ümmügül
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofWspolczesna Onkologia-Contemporary Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEwing's Sarcoma Family of Tumorsen_US
dc.subjectAdulten_US
dc.subjectTreatmenten_US
dc.titleClinical outcomes and prognostic factors of adult's Ewing sarcoma family of tumors: single center experienceen_US
dc.typeArticleen_US

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