Evaluation of aqueous humor and serum cortistatin levels in diabetic patients with and without diabetic retinopathy

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dc.authorid0000-0001-8857-994Xen_US
dc.authorid0000-0003-1337-459X
dc.authorid0000-0003-4468-3985
dc.authorid0000-0001-6951-8260
dc.contributor.authorBalbaba, Mehmet
dc.contributor.authorUlaş, Fatih
dc.contributor.authorErdağ, Murat
dc.contributor.authorYıldırım, Hakan
dc.contributor.authorÇeliker, Ülkü
dc.contributor.authorAydın, Süleyman
dc.date.accessioned2021-06-23T19:17:12Z
dc.date.available2021-06-23T19:17:12Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: To evaluate the aqueous humor and serum cortistatin levels in diabetic patients with and without diabetic retinopathy and its relationship with various metabolic markers that have been reported to be associated with diabetes mellitus. Methods: The current study included 20 diabetes mellitus patients with diabetic retinopathy, 20 diabetes mellitus patients without diabetic retinopathy, and 20 healthy control subjects with the same sex and age characteristics. Aqueous humor and serum cortistatin, fasting blood glucose, hemoglobinA1c, 25-hydroxyvitamin D levels, blood lipid profiles, and body mass index were measured in all subjects. Results: In diabetic patients with and without diabetic retinopathy and in healthy control subjects, the mean aqueous humor cortistatin levels were 25.55 +/- 2.03, 27.71 +/- 2.01, and 32.76 +/- 3.43 ng/mL, respectively. Likewise, the mean serum cortistatin levels were 6.16 +/- 1.08, 6.57 +/- 1.00, and 7.56 +/- 1.51 ng/mL, respectively. Aqueous humor cortistatin levels were decreased in diabetic patients with and without diabetic retinopathy when compared to healthy controls (p < 0.001). Although aqueous humor cortistatin levels tended to be reduced in diabetic patients with diabetic retinopathy, the difference was not statistically significant between diabetic patients with and without diabetic retinopathy (p = 0.147). Serum cortistatin levels were not statistically significant between diabetic patients with and without diabetic retinopathy and healthy control subjects (p = 0.166). Body mass index, fasting blood glucose, and hemoglobinA1c levels were significantly different between the groups (p < 0.05 for all parameters tested). Conclusion: Aqueous humor cortistatin levels were decreased in diabetic patients with and without diabetic retinopathy. The results suggest that a local decrease in the amount of cortistatin may play a role in the pathogenesis of diabetic retinopathy.en_US
dc.identifier.doi10.1177/1120672119894847
dc.identifier.endpage642
dc.identifier.issn1120-6721
dc.identifier.issue2
dc.identifier.pmid31822132en_US
dc.identifier.scopus2-s2.0-85077306200en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage638
dc.identifier.urihttps://doi.org/10.1177/1120672119894847
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5283
dc.identifier.volume31
dc.identifier.wosWOS:000502200000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlaş, Fatih
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofEuropean Journal Of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBody Mass Indexen_US
dc.subjectCortistatinen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectDiabetic Retinopathyen_US
dc.subjectGlucoseen_US
dc.subjectVitamin Den_US
dc.subjectBlood Lipiden_US
dc.titleEvaluation of aqueous humor and serum cortistatin levels in diabetic patients with and without diabetic retinopathyen_US
dc.typeArticleen_US

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