Botulinum toxin monotherapy for the treatment of essential tremor: life quality effect

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dc.authorid0000-0003-4221-2506
dc.contributor.authorDemiryürek, Bekir Enes
dc.date.accessioned2021-06-23T18:57:10Z
dc.date.available2021-06-23T18:57:10Z
dc.date.issued2021
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAIM: This study aims to evaluate the effectiveness of botulinum toxin therapy, as a monotherapy, and its effect on quality of life in patients with essential tremor (ET) who are resistant to medical treatment or cannot tolerate optimum drug doses in the population. METHOD: This retrospective research was conducted between February 2019 and December 2019 with 15 adult patients (9 men and 6 women) in the 50-to-70 age group, who had a definite diagnosis of ET as evaluated by the same clinician. With the help of electroneuromyography, intramuscular onabotulinum toxin A (BoNT-A) injection was administered to the related muscles, not exceeding 100 U in total. Demographic characteristics and duration of disease of all patients were recorded. The tremor severity of patients before the injection, 1 month after the injection, and 3 months after the injection was assessed by the Fahn-Tolosa-Marín Tremor Rating Scale (FTM-TRS), applied by the same clinician during the face-to-face interviews, in addition to the Questionnaire for Essential Tremor (QUEST), which was filled out by participants. RESULTS: The first month and third month mean QUEST and FTM-TRS scores were statistically lower than that before the procedure in patients with ET after BoNT-A injection (P = 0.001, P = 0.001, P = 0.001, and P = 0.001). In addition, the mean FTM-TRS and QUEST scores for the first month after the procedure were significantly lower than the mean FTM-TRS and QUEST scores for the third month (P = 0.005 and P = 0.007). CONCLUSION: We believe that our study is valuable because there is no research on the effect of BoNT-A administration on ET treatment in the our country population and because the effect of BoNT-A treatment on quality of life in patients with ET was evaluated using the ET-specific QUEST scale.en_US
dc.identifier.doi10.1097/WNF.0000000000000428
dc.identifier.endpage4en_US
dc.identifier.issn1537-162X
dc.identifier.issue1en_US
dc.identifier.pmid33449473en_US
dc.identifier.scopus2-s2.0-85100125044en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1097/WNF.0000000000000428
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5144
dc.identifier.volume44en_US
dc.identifier.wosWOS:000624037700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDemiryürek, Bekir Enes
dc.language.isoenen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofClinical Neuropharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEssential Tremoren_US
dc.subjectBotulinum Toxin
dc.subjectQuality of Life
dc.titleBotulinum toxin monotherapy for the treatment of essential tremor: life quality effecten_US
dc.typeArticleen_US

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