Effect of epidermal growth factor on rabbit urethral healing

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dc.authorid0000000215019324
dc.authorid0000-0002-5800-3306
dc.contributor.authorAǧartan, Canan Aldırmaz
dc.contributor.authorAktuǧ, Tanju
dc.contributor.authorGüven, Aysel
dc.contributor.authorDemir, Devrim
dc.contributor.authorÖner, Filiz
dc.contributor.authorÇam, Meryem
dc.date.accessioned2021-06-23T18:54:36Z
dc.date.available2021-06-23T18:54:36Z
dc.date.issued2004
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractExtensive clinical and laboratory studies have demonstrated epidermal growth factor (EGF) to play an essential role in the regeneration and healing of epithelial surfaces, including respiratory, gastrointestinal and genitourinary tracts. In this study, we evaluated the effects of supplemental EGF on urethral healing using a rabbit preparation. Twenty New Zealand White rabbits were separated into three groups. In group 1 longitudinal urethrotomy and urethral repair were performed (n=8). In group 2 urethrotomy and urethral repair were performed as in group 1 and gelatin gel patches (1.2 × 0.5 × 0.1 cm) were placed between the repaired urethra and the skin (n=6). In group 3 gel patches containing 10 ?g EGF were placed as in group 2 (n=6). Three weeks after surgery all rabbits were examined under anesthesia in order to determine macroscopic urethral fistulae, and the penis was harvested en bloc for histological examination. There was evidence of macroscopic fistulae formation in only one animal in group 3. Histological evaluation revealed no statistically significant difference between the groups (p>0.05). Despite literature suggesting beneficial effects of EGF on wound healing, we found no beneficial effects of EGF on urethral healing.en_US
dc.identifier.endpage76en_US
dc.identifier.issn1300-4182
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-21744432342en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage71en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4506
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-21744432342&partnerID=40&md5=f6e3bae2395da086aeb11e85d9c90601
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAǧartan, Canan Aldırmaz
dc.institutionauthorGüven, Aysel
dc.language.isoenen_US
dc.relation.ispartofFabad Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpidermal Growth Factoren_US
dc.subjectRabbitsen_US
dc.subjectUrethral Healingen_US
dc.subjectWound Healingen_US
dc.titleEffect of epidermal growth factor on rabbit urethral healingen_US
dc.typeArticleen_US

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