Effect of epidermal growth factor on rabbit urethral healing
Küçük Resim Yok
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Extensive clinical and laboratory studies have demonstrated epidermal growth factor (EGF) to play an essential role in the regeneration and healing of epithelial surfaces, including respiratory, gastrointestinal and genitourinary tracts. In this study, we evaluated the effects of supplemental EGF on urethral healing using a rabbit preparation. Twenty New Zealand White rabbits were separated into three groups. In group 1 longitudinal urethrotomy and urethral repair were performed (n=8). In group 2 urethrotomy and urethral repair were performed as in group 1 and gelatin gel patches (1.2 × 0.5 × 0.1 cm) were placed between the repaired urethra and the skin (n=6). In group 3 gel patches containing 10 ?g EGF were placed as in group 2 (n=6). Three weeks after surgery all rabbits were examined under anesthesia in order to determine macroscopic urethral fistulae, and the penis was harvested en bloc for histological examination. There was evidence of macroscopic fistulae formation in only one animal in group 3. Histological evaluation revealed no statistically significant difference between the groups (p>0.05). Despite literature suggesting beneficial effects of EGF on wound healing, we found no beneficial effects of EGF on urethral healing.
Açıklama
Anahtar Kelimeler
Epidermal Growth Factor, Rabbits, Urethral Healing, Wound Healing
Kaynak
Fabad Journal of Pharmaceutical Sciences
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
29
Sayı
2
