Histopathological and biochemical evaluation of the effect of Paeoniflorin on the periodontium during and after periodontitis formation in rats

Basit Öğe Kaydı
dc.authorid0000-0002-3711-6520en_US
dc.authorid0000-0002-1121-9978
dc.authorid0000-0002-4154-4675
dc.authorid0000-0002-2854-0856
dc.authorid0000-0003-1732-6173
dc.contributor.authorKurt, Sevda
dc.contributor.authorGürkan, Çağla Gül
dc.contributor.authorTezal, Gonca Çayır Keleş
dc.contributor.authorÇiftçi, Alper
dc.contributor.authorGürgör, Pınar Naile
dc.contributor.authorGüler, Şevki
dc.contributor.authorÇetinkaya, Burcu Özkan
dc.date.accessioned2021-06-23T19:51:34Z
dc.date.available2021-06-23T19:51:34Z
dc.date.issued2019
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalıen_US
dc.description.abstractObjectives: Appraise the effect of systemic Paeoniflorin (Pae) application on the periodontium during and after induction of experimental periodontitis in the presence of ligature and after its removal. Design: Seventy male Wistar rats were separated into seven equal groups. The first group was reserved as healthy control group (Group 1: no periodontitis, no medication) and experimental periodontitis was induced with ligature in the remaining rats. In experimental periodontitis groups, Pae or saline was administered systemically in three differet periods; during the experimental periodontitis induction (period 1), after experimental periodontitis induction which ligature removed (period 2) or ligature kept in position (period 3). Only, one of the groups acted as the control periodontitis group and received no treatment. Experimental periodontitis groups were as follows; Group 2: medication in period 1, Group 3: periodontitis and no medication, Group 4: medication in period 2, Group 5: saline application in period 2, Group 6: medication in period 3, Group 7: saline application in period 3. Matrix metalloproteinases-9 (MMP-9) levels and interleukin-10 (IL-10) levels were detected biochemically and histomorphometric analyses were performed. These analyses included measurements of the area of alveolar bone, the level of alveolar bone, and attachment loss. Results: Area of alveolar bone and IL-10 levels were higher in the Pae-administered groups; level of alveolar bone, attachment loss, and MMP-9 levels were correspondingly lower (P < 0.05). The beneficial effects at histomorphometrical and biochemical levels of Pae were the strongest in the rats that were administered Pae after the removal of ligature. Conclusions: Systemically administered Pae had a positive effect on the healing of periodontal tissues. Pae can be used as a new therapeutic agent for periodontal diseases, but microbiology-based studies and more extensive biochemistry-based experimental and clinical studies are needed to address this possibility.en_US
dc.identifier.doi10.1016/j.archoralbio.2019.04.006
dc.identifier.endpage140en_US
dc.identifier.issn0003-9969
dc.identifier.issn1879-1506
dc.identifier.pmid31005686en_US
dc.identifier.scopus2-s2.0-85064322698en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage135en_US
dc.identifier.urihttps://doi.org/10.1016/j.archoralbio.2019.04.006
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10010
dc.identifier.volume102en_US
dc.identifier.wosWOS:000471206900018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGüler, Şevki
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofArchives Of Oral Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExperimental Periodontitisen_US
dc.subjectHistologyen_US
dc.subjectMatrix Metalloproteinase(s)en_US
dc.subjectCytokinesen_US
dc.titleHistopathological and biochemical evaluation of the effect of Paeoniflorin on the periodontium during and after periodontitis formation in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
sevda-kurt.pdf
Boyut:
6.61 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Periodontoloji Ana Bilim Dalı Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu