The effect of melatonin on tinnitus with respect to sleep and depression : a randomized clinical trial

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dc.authorid0000-0001-6541-0666
dc.authorid0000-0002-3345-5066
dc.contributor.authorKöybaşı, Serap
dc.contributor.authorBoztaş, Mehmet Hamid
dc.contributor.authorBiçer, Yusuf Özgür
dc.contributor.authorSerin, Erdinç
dc.contributor.authorSüslü, Ahmet Emre
dc.contributor.authorFunda, Yasemin Ongun
dc.contributor.authorŞereflican, Murat
dc.date.accessioned2021-06-23T19:33:59Z
dc.date.available2021-06-23T19:33:59Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: In this study we aimed to investigate the psychological status of tinnitus patients as well as the sleep quality and their relation to handicap caused by tinnitus using various scales. Additionally, serum melatonin levels and the effectiveness of melatonin treatment were studied. Study Design: Prospective, double blind, randomized controlled trial Materials and Methods: Patients were divided randomly into two groups as study (melatonin, n=13) and placebo (control, n=11) groups. Tinnitus Handicap Inventory (THI), Symptom Check List (SCL), Hospital Anxiety and Depression Scale (HAD), Beck Depression Inventory (BDI), Pittsburg Sleep Qualty Index (PSQI) were applied. After filling the scales and giving the venous blood sample for melatonin measurements the patients were instructed to take one tablet (placebo or 3 mg melatonin) before sleep every night. After 8 weeks, second order scales were filled and melatonin measurements were repeated. Results: Serum melatonin levels were between 1-260 pg/ml; the mean was 38,7 pg/ml. The correlation of melatonin levels with THI and tinnitus duration was not significant. THI was found to correlate with different measures of the PSQI, HAD, and BDI in both groups. Statistical analysis failed to show any significant difference within and between groups in respect of anxiety, depressive symptoms and sleep as well as melatonin and handicap levels. When the groups were assessed according to the THI severity (mild/moderate to severe;THI2); in the control group there was significant differences in PSQI(1) and PSQI(1) (p=0.0008, p=0.18), NAD(1), HAD(2) (0.002, 0.03), HAD Depression(1-2) (0.0, 0.006) BDI (p=0.007) PSQI(2 sleep) (disturbance) (P=0.018) parameters. However, in the melatonin group it was found that there were significant differences in SCL2 (sleep) (latency), PSQI(2) (sleep) (duration) and total PSQI(2) parameters. (p=0.022, 0.027, 0.006 respectively) Conclusion: Patients with higher handicap may benefit melatonin in respect of sleep latency and duration as well as sleep quality comparing with the patients taking placebo. Moreover, melatonin efficiency may be related to its antidepressive effect.en_US
dc.identifier.endpage208en_US
dc.identifier.issn1308-7649
dc.identifier.issn2148-3817
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7320
dc.identifier.urihttps://search.ebscohost.com/login.aspx?direct=true&db=asn&AN=78402411&lang=tr&site=eds-live
dc.identifier.volume8en_US
dc.identifier.wosWOS:000307083900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKöybaşı, Serap
dc.institutionauthorBoztaş, Mehmet Hamid
dc.institutionauthorBiçer, Yusuf Özgür
dc.institutionauthorŞereflican, Murat
dc.institutionauthorFunda, Yasemin Ongun
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofJournal Of International Advanced Otologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe effect of melatonin on tinnitus with respect to sleep and depression : a randomized clinical trialen_US
dc.typeArticleen_US

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