A green synthesis of new 3-aryl-4-phenylsulfonyl-5-aminoisoxazoles

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dc.authorid0000-0003-4740-1138
dc.authorid0000-0003-2159-7056
dc.contributor.authorAltuğ, Cevher
dc.contributor.authorBüyükbayram, Muhammet
dc.contributor.authorKavas, Özge
dc.contributor.authorYavuz, Muhsine Zeynep
dc.date.accessioned2021-06-23T19:35:51Z
dc.date.available2021-06-23T19:35:51Z
dc.date.issued2014
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.description.abstractThe present work describes a new protocol for the synthesis of 5-aminoisoxazoles using alpha-chlorooximes and 2-phenylsulfonyl acetonitrile via green chemistry routes. The titled 5-aminoisoxazoles 3 were further reacted with 4-nitrobenzoyl chloride to obtain 5-amidoisoxazoles with moderate yields. These heterocyclic compounds were tested in vitro MTT study to investigate inhibitive abilities to some cancer cell lines (C3a, L929, T98g and Mcf-7) and compounds 3a, 3c, 3e and 3h showed noticeable cytotoxic property against four cancer cell lines. (C) 2014 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.tet.2014.03.106
dc.identifier.endpage3594en_US
dc.identifier.issn0040-4020
dc.identifier.issue22en_US
dc.identifier.scopus2-s2.0-84899621420en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3590en_US
dc.identifier.urihttps://doi.org/10.1016/j.tet.2014.03.106
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7879
dc.identifier.volume70en_US
dc.identifier.wosWOS:000336868200008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAltuğ, Cevher
dc.institutionauthorBüyükbayram, Muhammet
dc.institutionauthorKavas, Özge
dc.institutionauthorYavuz, Muhsine Zeynep
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTetrahedronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGreen Chemistryen_US
dc.subjectAlpha-Chlorooximesen_US
dc.subject5-Aminoisoxazolesen_US
dc.subjectMITen_US
dc.titleA green synthesis of new 3-aryl-4-phenylsulfonyl-5-aminoisoxazolesen_US
dc.typeArticleen_US

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