A green synthesis of new 3-aryl-4-phenylsulfonyl-5-aminoisoxazoles

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Küçük Resim

Tarih

2014

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Pergamon-Elsevier Science Ltd

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

The present work describes a new protocol for the synthesis of 5-aminoisoxazoles using alpha-chlorooximes and 2-phenylsulfonyl acetonitrile via green chemistry routes. The titled 5-aminoisoxazoles 3 were further reacted with 4-nitrobenzoyl chloride to obtain 5-amidoisoxazoles with moderate yields. These heterocyclic compounds were tested in vitro MTT study to investigate inhibitive abilities to some cancer cell lines (C3a, L929, T98g and Mcf-7) and compounds 3a, 3c, 3e and 3h showed noticeable cytotoxic property against four cancer cell lines. (C) 2014 Elsevier Ltd. All rights reserved.

Açıklama

Anahtar Kelimeler

Green Chemistry, Alpha-Chlorooximes, 5-Aminoisoxazoles, MIT

Kaynak

Tetrahedron

WoS Q Değeri

Q2

Scopus Q Değeri

Q2

Cilt

70

Sayı

22

Künye