The effects of vasoactive intestinal peptide on dura mater nitric oxide levels and vessel-contraction responses in sympathectomized rats

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dc.authorid0000-0003-1410-740Xen_US
dc.authorid0000-0001-5912-9392
dc.contributor.authorTöre, Fatma
dc.contributor.authorKorkmaz, Orhan Tansel
dc.contributor.authorDoğrukol-Ak, Dilek
dc.contributor.authorTunçel, Neşe
dc.date.accessioned2021-06-23T19:26:59Z
dc.date.available2021-06-23T19:26:59Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractNitric oxide (NO) and neurogenic inflammation in dura mater due to nociceptor activation has been implicated for pathophysiology of primary headache disorders. Development of migraine has also been observed in patients treated with ganglion blockage for sympathetic reflex dystrophy. Vasoactive intestinal peptide (VIP) is an antioxidant, anti-inflammatory, and neuroprotective neuropeptide. This study is intended to investigate the effects of VIP on dura mater NO levels and vessel-contraction responses in sympathectomized rats. In the experiments, 30 male rats in five groups were used. Group 1 sympathectomized: under anesthesia, superior cervical sympathetic ganglion was removed via incision at the center line in the neck area. Group 2 sympathectomized + VIP: postoperative VIP of 25 ng/kg/day (0.2 ml) intraperitoneally administered to the rats exposed to the same operations for 5 days. Group 3 sham: ganglia and nerves were exposed but not dissected. Group 4 control: no treatment was done. Group 5 VIP: only VIP was administered for 5 days. Sympathectomy induced a significant increase in dura mater NO levels and VIP decreased NO to control levels and increased the norepinephrine vessel-contraction responses of sympathectomized rats. VIP is an efficient NO modulator in superior cervical ganglionectomized rats.en_US
dc.identifier.doi10.1007/s12031-009-9310-8
dc.identifier.endpage293en_US
dc.identifier.issn0895-8696
dc.identifier.issn1559-1166
dc.identifier.issue2en_US
dc.identifier.pmid19936638en_US
dc.identifier.scopus2-s2.0-77951621531en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage288en_US
dc.identifier.urihttps://doi.org/10.1007/s12031-009-9310-8
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6703
dc.identifier.volume41en_US
dc.identifier.wosWOS:000276882800008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTöre, Fatma
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofJournal Of Molecular Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMigraineen_US
dc.subjectVasoactive Intestinal Peptideen_US
dc.subjectDura Materen_US
dc.subjectNitric Oxideen_US
dc.titleThe effects of vasoactive intestinal peptide on dura mater nitric oxide levels and vessel-contraction responses in sympathectomized ratsen_US
dc.typeArticleen_US

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