Lipid peroxidation and scavenging enzyme levels in the liver of streptozotocin-induced diabetic rats

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dc.authorid0000-0001-9142-9061en_US
dc.authorid0000-0003-1691-618X
dc.authorid0000-0003-1937-9244
dc.authorid0000-0001-5175-4230
dc.authorid0000-0002-2076-3211
dc.contributor.authorBukan, Neslihan
dc.contributor.authorSancak, Banu
dc.contributor.authorYavuz, Özlem
dc.contributor.authorKoca, Cemile
dc.contributor.authorTutkun, Funda
dc.contributor.authorÖzçelikay, A. Tanju
dc.contributor.authorAltan, Nilgün
dc.date.accessioned2021-06-23T19:17:30Z
dc.date.available2021-06-23T19:17:30Z
dc.date.issued2003
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractIn this study, alterations in the liver antioxidant enzymes status and lipid peroxidation in short-term (8-weeks) and long-term (24-weeks) diabetic rats were examined. Glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) levels were significantly increased, but superoxide dismutase (SOD) activity was significantly reduced in 8-weeks diabetic rats, compared to control. Catalase (CAT) activity, however, was found unchanged. In 24-weeks diabetic rats, while GSH-Px activity was unchanged, but SOD and CAT activities and MDA levels were significantly increased, compared to control. These results suggest that diabetes-induced alterations, in tissue antioxidant system may reflect a generalized increase in tissue oxidative stress. It can be concluded that lipid peroxidation and antioxidant enzyme levels are elevated in diabetic condition. Hence, diabetes mellitus, if left untreated, may. increase. degenerative processes. due. to accumulation of oxidative. free radicals.en_US
dc.identifier.endpage450en_US
dc.identifier.issn0301-1208
dc.identifier.issue6en_US
dc.identifier.pmid22900374en_US
dc.identifier.scopus2-s2.0-5444253067en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage447en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5437
dc.identifier.urihttp://nopr.niscair.res.in/bitstream/123456789/3824/1/IBB%2040(6)%20447-450.pdf
dc.identifier.volume40en_US
dc.identifier.wosWOS:000188542000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYavuz, Özlem
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal Of Biochemistry & Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLipid Peroxidationen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectDiabetic Ratsen_US
dc.titleLipid peroxidation and scavenging enzyme levels in the liver of streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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