Apoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst. and kit

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dc.authorid0000-0001-5993-1668en_US
dc.contributor.authorGülçin, İlhami
dc.contributor.authorBeydemir, Şükrü
dc.contributor.authorTopal, Fevzi
dc.contributor.authorGagua, Natia
dc.contributor.authorBakuridze, Aliko
dc.contributor.authorBayram, Recep
dc.contributor.authorGepdiremen, Akçahan
dc.date.accessioned2021-06-23T19:29:24Z
dc.date.available2021-06-23T19:29:24Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIn the present study, apoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst. and Kit were studied. For testing the possible apoptotic effects of majdine and isomajdine from V. herbacea, DNA fragmentation assay was conducted on the rat brain cortical tissue homogenates, in vitro. Also their possible effects on mitochondrial activity were tested by using the same tissue samples of rats. In addition, the antioxidant activity of isomajdine and majdine was determined using various in vitro antioxidant assays, including 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS(center dot+)) radical scavenging and N,N-dimethyl-p-phenylenediamine (DMPD center dot+) radical scavenging, ferric ions (Fe3+) and cupric ions (Cu2+) reducing abilities and ferrous ions (Fe2+) chelating activity. On the other hand, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol and trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) were used as reference antioxidants.en_US
dc.identifier.doi10.3109/14756366.2011.604318
dc.identifier.endpage594en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue4en_US
dc.identifier.pmid21883037en_US
dc.identifier.scopus2-s2.0-84864048634en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage587en_US
dc.identifier.urihttps://doi.org/10.3109/14756366.2011.604318
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7165
dc.identifier.volume27en_US
dc.identifier.wosWOS:000306524200017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBayram, Recep
dc.institutionauthorGepdiremen, Akçahan
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Enzyme Inhibition And Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant Activityen_US
dc.subjectRadical Scavengingen_US
dc.subjectApoptotic Effecten_US
dc.subjectIsomajdineen_US
dc.subjectMajdineen_US
dc.titleApoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst. and kiten_US
dc.typeArticleen_US

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