The preventive effect of low molecular weight heparin on CCL4-induced necrosis and apoptosis in rat liver

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dc.authorid0000-0002-0901-9192en_US
dc.authorid0000-0001-5912-9392
dc.authorid0000-0003-3310-8803
dc.contributor.authorKükner, Aysel
dc.contributor.authorTöre, Fatma
dc.contributor.authorFırat, Tülin
dc.contributor.authorTerzi, E. Hakan
dc.contributor.authorÖner, Hakan
dc.contributor.authorBalaban, Hatice Yasemin
dc.date.accessioned2021-06-23T19:26:47Z
dc.date.available2021-06-23T19:26:47Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction Heparin having anti inflammatory and anti fibrotic properties may have therapeutic effect on liver injury The present study investigated the effect of low molecular weight heparin (Enoxaparin) on carbon tetrachloride (CCl4) induced hepatic necrosis and apoptosis in rats Material and methods Thirty male rats were divided into 5 groups Group I Control, Group II Olive oil dissolved CCl4 at dose of 1 mL/kg, ip, twice per week, Group III CCl4 and Enoxaparin at dose of 180 IU/kg, sc, daily, Group IV Enoxaparin, Group V Olive oil at dose of 1 mL, ip, twice per week The liver histology at the forth week was examined by haematoxylin eosin, Masson's trichrome, Toluidine blue and Periodic acid schiff stains Proliferative and apoptotic activities were assessed semi quantitatively by proliferating cell nuclear antigen (PCNA) and cas pase 3 immune staining and TUNEL method Semi quantitative values formulated by the equation HSCORE = Sigma P-i (1+1) including both distribution and intensity of staining Additionally, mdogen and a smooth muscle actin were labeled by immunohistochemistry Results CCl4 group had marked hepatocelluar necrosis around the vena centralis and increased inflammatory cells and mast cells Hepatocytes showed deposition of lipid droplets, decrease in glycogen, apoptosis, and picnotic or enlarged nuclei Enoxaparin reduced necrosis, apoptosis, and number of mast cells but had no effect on lipid droplets in hepatocytes HSCORE's of caspase 3 and PCNA were also significantly decreased by administration Conclusion Enoxaparin have beneficial effects against necrosis as well as apoptosis at the early stage of CCL4 induced liver injuryen_US
dc.identifier.doi10.1016/S1665-2681(19)31621-7
dc.identifier.endpage454en_US
dc.identifier.issn1665-2681
dc.identifier.issue4en_US
dc.identifier.pmid21057164en_US
dc.identifier.scopus2-s2.0-79952307115en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage445en_US
dc.identifier.urihttps://doi.org/10.1016/S1665-2681(19)31621-7
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6650
dc.identifier.volume9en_US
dc.identifier.wosWOS:000285909200009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKükner, Aysel
dc.institutionauthorTöre, Fatma
dc.language.isoenen_US
dc.publisherElsevier Espanaen_US
dc.relation.ispartofAnnals Of Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectEnoxaparinen_US
dc.subjectCCl4en_US
dc.subjectLiveren_US
dc.subjectPCNAen_US
dc.titleThe preventive effect of low molecular weight heparin on CCL4-induced necrosis and apoptosis in rat liveren_US
dc.typeArticleen_US

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