Sodium fusidate-poly(D,L-lactide-co-glycolide) microspheres: Preparation, characterisation and in vivo evaluation of their effectiveness in the treatment of chronic osteomyelitis

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dc.authorid0000-0002-0486-2252en_US
dc.contributor.authorCevher, Erdal
dc.contributor.authorOrhan, Zafer
dc.contributor.authorŞensoy, Demet
dc.contributor.authorAhıskalı, Rengin
dc.contributor.authorKan, Pei Lee
dc.date.accessioned2021-06-23T19:20:44Z
dc.date.available2021-06-23T19:20:44Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: The aim of this study was to prepare poly(D, L- lactide-co-glycolide) (PLGA) microspheres containing sodium fusidate ( SF) using a double emulsion solvent evaporation method with varying polymer: drug ratios (1: 1, 2.5: 1, 5: 1) and to evaluate its efficiency for the local treatment of chronic osteomyelitis. Methods: The particle size and distribution, morphological characteristics, thermal behaviour, drug content, encapsulation efficiency and in vitro release assessments of the formulations had been carried out. Sterilized SF-PLGA microspheres were implanted in the proximal tibia of rats with methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. After 3 weeks of treatment, bone samples were analysed with a microbiological assay. Results: PLGA microspheres between the size ranges of 2.16-4.12 mu m were obtained. Production yield of all formulations was found to be higher than 79% and encapsulation efficiencies of 19.8-34.3% were obtained. DSC thermogram showed that the SF was in an amorphous state in the microspheres and the glass transition temperature ( Tg) of PLGA was not influenced by the preparation procedure. In vitro drug release studies had indicated that these microspheres had significant burst release and their drug release rates were decreased upon increasing the polymer: drug ratio (p < 0.05). Based on the in vivo data, rats implanted with SF-PLGA microspheres and empty microspheres showed 1987 +/- 1196 and 55526 +/- 49086 colony forming unit of MRSA in 1 g bone samples (CFU/g), respectively (p < 0.01).en_US
dc.identifier.doi10.1080/02652040701472584
dc.identifier.endpage595en_US
dc.identifier.issn0265-2048
dc.identifier.issn1464-5246
dc.identifier.issue6en_US
dc.identifier.pmid17654177en_US
dc.identifier.scopus2-s2.0-34547507176en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage577en_US
dc.identifier.urihttps://doi.org/10.1080/02652040701472584
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6161
dc.identifier.volume24en_US
dc.identifier.wosWOS:000247967100007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOrhan, Zafer
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Microencapsulationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSodium fusidateen_US
dc.subjectPoly(D,L-lactide-co-glycolide) microspheresen_US
dc.subjectEmulsion solvent evaporation methoden_US
dc.subjectMethicillin-resistant Staphylococcus aureusen_US
dc.subjectChronic osteomyelitisen_US
dc.titleSodium fusidate-poly(D,L-lactide-co-glycolide) microspheres: Preparation, characterisation and in vivo evaluation of their effectiveness in the treatment of chronic osteomyelitisen_US
dc.typeArticleen_US

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