DNA-bioprotective effects of lactic acid bacteria against aflatoxin B-1

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dc.authorid0000-0003-2242-0703en_US
dc.authorid0000-0001-7775-1871
dc.contributor.authorKurhan, Şebnem
dc.contributor.authorÇakır, İbrahim
dc.date.accessioned2021-06-23T19:43:00Z
dc.date.available2021-06-23T19:43:00Z
dc.date.issued2016
dc.departmentBAİBÜ, Rektörlük, Yenilikçi Gıda Teknolojileri Geliştirme Uygulama ve Araştırma Merkezien_US
dc.departmentBAİBÜ, Mühendislik Fakültesi, Gıda Mühendisliği Bölümü
dc.description.abstractLactic acid bacteria commonly named as probiotics have a broad range of utilization area in human diet and food industry. Besides these known properties of probiotics, in recent years many researchers have focused on their anti-genotoxic called DNA-bioprotective effects. Human gets exposure with genotoxins such as mycotoxins, polycyclic aromatic hydrocarbons, and n-nitroso-compounds through diet and environmental contaminations. Aflatoxin B-1 is mycotoxin which was reported one of the most potent hepato-carcinogen and its exposure stems from human diet. In this study, we aimed to investigate DNA-bioprotective effect of Lactobacillus plantarum on human colon adenocarcinoma (Caco-2) cells against Aflatoxin B-1 (AFB(1)) with comet assay without metabolic activation. The results showed that DNA-bioprotective effect of L. plantarum did reduce the AFB(1)'s genotoxic effect on colon adenocarcinoma (Caco-2) cells. Positive control (50 iM H2O2 applied) and high dose (>10ppm) AFB(1) applied cells have the same comet tail appearance. Only visual scoring is performed. Besides negative control cells (Only PBS) and Lactobacillus plantarum+AFB(1) mixture showed the same manner with each other; no comet tail detected. These results clearly indicate that L. plantarum is capable of reduce AFB(1) safely without producing any by-products.en_US
dc.identifier.doi10.12944/CRNFSJ.4.Special-Issue-October.11
dc.identifier.endpage91en_US
dc.identifier.issn2347-467X
dc.identifier.issn2322-0007
dc.identifier.scopus2-s2.0-85016074939en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage87en_US
dc.identifier.urihttps://doi.org/10.12944/CRNFSJ.4.Special-Issue-October.11
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8666
dc.identifier.volume4en_US
dc.identifier.wosWOS:000453279100011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÇakır, İbrahim
dc.institutionauthorKurhan, Şebnem
dc.language.isoenen_US
dc.publisherEnviro Research Publishersen_US
dc.relation.ispartofCurrent Research In Nutrition And Food Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProbioticsen_US
dc.subjectAflatoxin B-1en_US
dc.subjectL. Plantarumen_US
dc.subjectComet Assay (SCGE)en_US
dc.titleDNA-bioprotective effects of lactic acid bacteria against aflatoxin B-1en_US
dc.typeArticleen_US

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