Association of Genetic Polymorphisms in Vitamin D Receptor Gene and Susceptibility to Sporadic Prostate Cancer

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dc.contributor.authorÖnen, İlke Hacer
dc.contributor.authorEkmekçi, Abdullah
dc.contributor.authorEroğlu, Muzaffer
dc.contributor.authorKonaç, Ece
dc.contributor.authorYeşil, Süleyman
dc.date.accessioned2021-06-23T19:20:54Z
dc.date.available2021-06-23T19:20:54Z
dc.date.issued2008
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description7th National Congress on Prenatal Diagnosis and Medical Genetics -- MAY 17-20, 2006 -- Kayseri, TURKEYen_US
dc.description.abstractGenetic and environmental factors are involved in prostate cancer (PCa) etiology. Single nucleotide polymorphisms (SNPs) may contribute to the PCa pathogenesis. The goal of this study is to determine the role of vitamin D receptor (VDR) gene polymorphisms and haplotypes in the development and progression of sporadic PCa. One hundred and thirty-three PCa patients and 157 age-matched healthy controls were genotyped for the ApaI (rs7975232), BsmI (rs1544410) and TaqI (rs731236) polymorphisms in VDR gene by using polymerase chain reaction-restriction fragment length polymorphism. An association was observed between the ApaI polymorphism and PCa predisposition (P = 0.03). When compared with AA genotype, there was a highly notable difference in the frequencies of the Aa (P = 0.02), aa (P = 0.026) and ApaI "a" allele carriers (Aa + aa) (P = 0.009) genotypes. Furthermore, we found a statistical difference in the allele frequencies of the ApaI polymorphism between the sporadic PCa patients and control subjects (P = 0.013). The genotype distribution for the BsmI and TaqI polymorphisms were similar between cases and controls (P > 0.05). No clinically significant relationship was found between the three-locus haplotypes and development of sporadic PCa. The genotype frequencies for the three polymorphisms of the VDR gene within subgroups of PCa (defined by tumor stage, Gleason score, PSA levels) were also analyzed, but no statistically noteworthy difference was observed (P > 0.05). As far as we know, this is the first study which investigates the relationship between VDR genotypes and sporadic PCa in the Turkish population. Our findings suggest that the VDR ApaI (rs7975232) polymorphism may play a role in the development of sporadic PCa. Exp Biol Med 233:1608-1614, 2008en_US
dc.identifier.doi10.3181/0803-RM-110
dc.identifier.endpage1614en_US
dc.identifier.issn1535-3702
dc.identifier.issn1535-3699
dc.identifier.issue12en_US
dc.identifier.pmid18849534en_US
dc.identifier.scopus2-s2.0-58749095728en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1608en_US
dc.identifier.urihttps://doi.org/10.3181/0803-RM-110
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6185
dc.identifier.volume233en_US
dc.identifier.wosWOS:000261561500019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEroğlu, Muzaffer
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofExperimental Biology And Medicineen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVDR geneen_US
dc.subjectPolymorphismen_US
dc.subjectSNPen_US
dc.subjectProstate Canceren_US
dc.titleAssociation of Genetic Polymorphisms in Vitamin D Receptor Gene and Susceptibility to Sporadic Prostate Canceren_US
dc.typeConference Objecten_US

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Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
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