Serum brain-derived neurotrophic factor levels in treatment?naïve boys with attention-deficit/hyperactivity disorder treated with methylphenidate: an 8-week, observational pretest-posttest study

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dc.authorid0000-0001-5207-6240en_US
dc.authorid0000-0003-3775-0211en_US
dc.contributor.authorAkay, Aynur Pekcanlar
dc.contributor.authorResmi, Halil
dc.contributor.authorGüney, Sevay Alsen
dc.contributor.authorErkuran, Handan Özek
dc.contributor.authorÖzyurt, Gonca
dc.contributor.authorSargın, Enis
dc.contributor.authorTopuzoğlu, Ahmet
dc.contributor.authorTufan, Ali Evren
dc.date.accessioned2021-06-23T19:50:21Z
dc.date.available2021-06-23T19:50:21Z
dc.date.issued2018
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBrain-derived neurotrophic factor (BDNF) is an important neurotrophin in the brain that modulates dopaminergic neurons. In this study, we aimed to investigate the changes in serum BDNF levels of children with attention-deficit/hyperactivity disorder (ADHD) in response to OROS methylphenidate treatment. We also aimed to determine whether there were any pre-post-differences between ADHD subtypes and comorbid psychiatric disorders in serum BDNF levels. Fifty male children with ADHD and 50 male healthy controls within the age range of 6-12 years were recruited to the study. The psychiatric diagnoses were determined by applying a structured interview with Kiddie schedule for affective disorders and schizophrenia for school-age children-present and lifetime version. The symptom severity of ADHD was measured using the Clinical Global Impression ADHD Severity Scale (CGI-S). Physicians completed Du Paul ADHD questionnaires. The levels of serum BDNF were assessed before and after 8 weeks of treatment with effective dosages of OROS methylphenidate. In the present study, the mean serum BDNF levels of boys with ADHD and of the healthy controls were 2626.33 +/- 1528.05 and 2989.11 +/- 1420.08 pg/mL, respectively. Although there were no statistically significant difference between the ADHD group and healthy controls at baseline (p = 0.22), the increase of serum BDNF was statistically significant from baseline to endpoint in the ADHD group (p = 0.04). The mean serum BDNF levels at baseline and endpoint of the ADHD group were 2626.33 +/- 1528.05 and 3255.80 +/- 1908.79 pg/mL, respectively. The serum BDNF levels of ADHD-inattentive subtype were significantly lower at baseline (p = 0.02), whereas BDNF levels post-treatment showed no significant difference. The increase of serum BDNF levels with methylphenidate treatment after 8 weeks was significantly higher in the inattentive group (p = 0.005). The increase of serum BDNF levels with methylphenidate treatment after 8 weeks in boys with ADHD may support the potential role of BDNF in the pathophysiology of ADHD. The role of BDNF in ADHD subtypes in particular should be evaluated with further, larger studies.en_US
dc.identifier.doi10.1007/s00787-017-1022-y
dc.identifier.endpage135en_US
dc.identifier.issn1018-8827
dc.identifier.issn1435-165X
dc.identifier.issue1en_US
dc.identifier.pmid28710695en_US
dc.identifier.scopus2-s2.0-85023762749en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://doi.org/10.1007/s00787-017-1022-y
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9763
dc.identifier.volume27en_US
dc.identifier.wosWOS:000424336300013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTufan, Ali Evren
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Child & Adolescent Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain-derived neurotrophic factoren_US
dc.subjectAttention-deficit/hyperactivity Disorderen_US
dc.subjectChildrenen_US
dc.subjectMethylphenidateen_US
dc.titleSerum brain-derived neurotrophic factor levels in treatment?naïve boys with attention-deficit/hyperactivity disorder treated with methylphenidate: an 8-week, observational pretest-posttest studyen_US
dc.typeArticleen_US

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