Evaluation of the dynamic thiol/disulfide homeostasis in patients with chronic venous insufficiency

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dc.authorid0000-0002-1678-1281
dc.authorid0000-0002-3394-2438
dc.authorid0000-0003-4709-4705
dc.authorid0000-0003-0165-0809
dc.contributor.authorMüdüroğlu, Ayhan
dc.contributor.authorVelioğlu, Yusuf
dc.contributor.authorÇelik, Hümeyra
dc.contributor.authorYüksel, Ahmet
dc.contributor.authorAldemir, Mustafa
dc.contributor.authorAtasoy, Mustafa Selçuk
dc.contributor.authorKılıç, Ali Önder
dc.date.accessioned2024-09-25T19:56:32Z
dc.date.available2024-09-25T19:56:32Z
dc.date.issued2024
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractObjective: There is no study in the literature evaluating the dynamic thiol/disulfide homeostasis in patients with chronic venous insufficiency. Thus, we designed this study to evaluate the dynamic thiol/disulfide homeostasis as a novel indicator of oxidative stress in patients with chronic venous insufficiency.Methods: This was a prospective case-control study performed at the department of cardiovascular surgery of a tertiary referral hospital in Turkey. A total of 80 (CEAP C3-C6) patients with lower extremity chronic venous insufficiency (as the study group) and 80 healthy subjects (as the control group) were enrolled to the study. The participants' basic demographic and clinical characteristics as well as serum levels of some laboratory parameters including albumin, ferroxidase, myeloperoxidase, native thiol, total thiol, disulphide, native thiol/total thiol, disulphide/native thiol, and disulphide/total thiol were determined, and then compared between the groups. Results: In terms of basic demographic and clinical characteristics, both groups were statistically similar, and there were no significant differences between the groups. When the laboratory parameters were considered, serum ferroxidase and myeloperoxidase levels were detected to be significantly higher, whereas albumin, native thiol, total thiol, and disulphide levels were detected to be significantly lower in the study group than in the control group. Conclusions: Dynamic thiol/disulphide homeostasis could be considered as an indicator reflecting the oxidative stress status in patients with chronic venous insufficiency. (J Vasc Surg Venous Lymphat Disord 2024;12:101689.)en_US
dc.identifier.doi10.1016/j.jvsv.2023.09.003
dc.identifier.endpage9
dc.identifier.issn2213-333X
dc.identifier.issue1en_US
dc.identifier.pmid37788743en_US
dc.identifier.scopus2-s2.0-85175162744en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.jvsv.2023.09.003
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13322
dc.identifier.volume12en_US
dc.identifier.wosWOS:001147867700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇelik, Hümeyra
dc.institutionauthorid0000-0002-3394-2438
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Vascular Surgery-Venous And Lymphatic Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectBiomarkeren_US
dc.subjectChronic Venous Insuf Fi Ciencyen_US
dc.subjectDynamic Thiol/Disul Fi De Homeostasisen_US
dc.subjectOxidative Stressen_US
dc.titleEvaluation of the dynamic thiol/disulfide homeostasis in patients with chronic venous insufficiencyen_US
dc.typeArticleen_US

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