Comparison of the effectiveness of Ankaferd Blood Stopper® and Emdogain in periodontal regeneration

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dc.authorid0000-0002-2854-0856en_US
dc.authorid0000-0002-9898-6132en_US
dc.authorid0000-0002-3711-6520en_US
dc.authorid0000-0003-4411-2496en_US
dc.authorid0000-0002-1121-9978en_US
dc.contributor.authorGüler, Şevki
dc.contributor.authorÇetinkaya, Burcu Özkan
dc.contributor.authorBayrakdar, Sevda Kurt
dc.contributor.authorAyas, Bülent
dc.contributor.authorKeleş, Gonca Çayır
dc.date.accessioned2023-06-20T11:49:37Z
dc.date.available2023-06-20T11:49:37Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalıen_US
dc.descriptionOndokuz Mayis Research Fund, Grant/Award Number: PYO.DIS.1904.14.002en_US
dc.description.abstractObjectives The present study was performed to compare the effectiveness of Ankaferd Blood Stopper(R) (ABS) with enamel matrix derivatives (EMD) for treating fenestration defects in rats. Materials and Methods Forty-eight male Wistar rats were randomly divided into six groups (each n = 8). Fenestration defects were created in all rats, to which ABS, EMD, or saline (S) was then applied. The rats were grouped and sacrificed at one of two different time points, as follows: ABS-10-group, ABS-treatment/sacrifice on day 10; EMD-10-group, EMD-treatment/sacrifice on day 10; S-10-group, S-treatment/sacrifice on day 10; ABS-38-group, ABS-treatment/sacrifice on day 38; EMD-38-group, EMD-treatment/sacrifice on day 38; and S-38-group, S-treatment/sacrifice on day 38. Then, histomorphometric analysis including measurements of new bone area (NBA) and new bone ratio (NBR), and immunohistochemical analysis including the determination of osteopontin (OPN) and type-III-collagen (C-III) expression were performed. Results The NBA and NBR were significantly higher in the ABS-10-group and EMD-10-group compared to the S-10-group (p < .05), and in the EMD-38-group compared to the S-38-group (p < .05). The levels of C-III and OPN immunoreactivity were significantly higher in the ABS-10-group compared to the S-10-group (p < .017). Conclusions The results of this study suggested that ABS can promote early periodontal regeneration, although its efficacy seems to decrease over time.en_US
dc.description.sponsorshipOndokuz Mayis Research Fund [PYO.DIS.1904.14.002]en_US
dc.identifier.citationGüler, Ş., Cetinkaya, B. O., Kurt Bayrakdar, S., Ayas, B., & Keles, G. C. (2022). Comparison of the effectiveness of Ankaferd Blood Stopper® and Emdogain in periodontal regeneration. Oral diseases, 28(7), 1947-1957.en_US
dc.identifier.doi10.1111/odi.13852
dc.identifier.endpage1957en_US
dc.identifier.issn1354-523X
dc.identifier.issn1601-0825
dc.identifier.issue7en_US
dc.identifier.pmid33740823en_US
dc.identifier.scopus2-s2.0-85103933341en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1947en_US
dc.identifier.urihttp://dx.doi.org/10.1111/odi.13852
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11154
dc.identifier.volume28en_US
dc.identifier.wosWOS:000635543900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGüler, Şevki
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofOral Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkaferd Blood Stopperen_US
dc.subjectEmdogainen_US
dc.subjectHistomorphometricen_US
dc.subjectOsteopontinen_US
dc.subjectType-III Collagenen_US
dc.titleComparison of the effectiveness of Ankaferd Blood Stopper® and Emdogain in periodontal regenerationen_US
dc.typeArticleen_US

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