Protective effects of CAPE on liver injury induced by CCL4: An electron microscopy study

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dc.contributor.authorÇolakoğlu, Neriman
dc.contributor.authorKuş, İlter
dc.contributor.authorKükner, Aysel
dc.contributor.authorPekmez, Hıdır
dc.contributor.authorOzan, Enver
dc.contributor.authorSarsılmaz, Mustafa
dc.date.accessioned2024-09-25T20:01:40Z
dc.date.available2024-09-25T20:01:40Z
dc.date.issued2011
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü en_US
dc.description.abstractThis study was designed to investigate the protective effects of caffeic acid phenethyl ester on carbon tetrachloride-induced liver damage in rats. Twenty-four male Wistar rats were divided in three groups. Group I was used as control. Rats in group II were injected with carbon tetrachloride every other day for 1 month, whereas rats in group III were injected with carbon tetrachloride and caffeic acid phenethyl ester every other day for 1 month. At the end of the experiment, all animals were killed by decapitation and their livers were removed. Liver tissues were processed for electron microscopy. Histopathologically, hepatocytes of rats treated with carbon tetrachloride had damage in the cytoplasmic organelles and nuclei membranes as well as an excessive lipid accumulation in the hepatocytes. However, those histopathological changes were reduced with the coadministration of carbon tetrachloride and caffeic acid phenethyl ester. We conclude that caffeic acid phenethyl ester treatment has the capability to prevent carbon tetrachloride-induced liver damage in rats.en_US
dc.identifier.doi10.3109/01913123.2010.527036
dc.identifier.endpage30en_US
dc.identifier.issn0191-3123
dc.identifier.issue1en_US
dc.identifier.pmid21265632en_US
dc.identifier.startpage26en_US
dc.identifier.urihttps://doi.org/10.3109/01913123.2010.527036
dc.identifier.urihttps://hdl.handle.net/20.500.12491/14249
dc.identifier.volume35en_US
dc.identifier.wosWOS:000286892700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKükner, Aysel
dc.institutionauthorid0000-0001-5387-2628
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofUltrastructural Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectCaffeic
dc.subjectAnimals
dc.subjectCarbon Tetrachlorid
dc.subjectAcid Phenethyl
dc.subjectCoadministration
dc.subjectLiver Damage
dc.titleProtective effects of CAPE on liver injury induced by CCL4: An electron microscopy studyen_US
dc.typeArticleen_US

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