The effect of TNF-alpha blockers on psychometric measures in ankylosing spondylitis patients: a preliminary observation

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dc.authorid0000-0003-1710-7018en_US
dc.authorid0000-0002-1422-1600en_US
dc.contributor.authorArısoy, Özden
dc.contributor.authorBes, Cemal
dc.contributor.authorÇifçi, Çiğdem
dc.contributor.authorSercan, Mustafa
dc.contributor.authorSoy, Mehmet
dc.date.accessioned2021-06-23T19:34:29Z
dc.date.available2021-06-23T19:34:29Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThere is a high co-morbidity between chronic inflammatory disorders and depression. Proinflammatory cytokines like TNF-alpha seem to play a central role in the pathogenesis of these disorders, and its neutralization provides a potent treatment for inflammatory disorders. Few studies showed that TNF-alpha blockers also caused an improvement in depressive symptoms associated with these chronic inflammatory disorders. To evaluate the effectiveness of TNF-alpha blockers on symptoms of ankylosing spondylitis (AS), depression, anxiety and quality of life, 9 AS patients resistant to classical therapy were enrolled and followed-up at 2nd and 6th weeks after a TNF-alpha blocker was started. Hamilton Depression and Anxiety Scales (HAM-D, HAM-A), Hospital Depression and Anxiety Questionnaire (HAD), Quality of Life Scale (SF36) and AS severity index (BASDAI) were applied to the patients at weeks 0, 2 and 6. ESR and CRP were evaluated to monitor biological disease activity. There was a significant reduction in HAM-D (p = 0.00), HAM-A (p = 0.00), HAD anxiety scores (p = 0.02) and a significant improvement in SF36 physical function (p = 0.00), physical role limitations (p = 0.00), bodily pain (p = 0.05), general health (p = 0.01), vitality (p = 0.03) and emotional role limitations (p = 0.00) subscales, BASDAI scores (p = 0.00), ESR (p = 0.00) and CRP (p = 0.00). Change in clinical disease activity (BASDAI) was not correlated with change in depression-anxiety scores, while change in biological disease activity (CRP) was correlated with change in depression-anxiety scores. TNF alpha blockers may have a potential antidepressant effect besides its anti-inflammatory effect that seems to be independent of its clinical effect.en_US
dc.identifier.doi10.1007/s00296-013-2671-x
dc.identifier.endpage1864en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue7en_US
dc.identifier.pmid23334426en_US
dc.identifier.scopus2-s2.0-84879690397en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1855en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-013-2671-x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7526
dc.identifier.volume33en_US
dc.identifier.wosWOS:000321259500027en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorArısoy, Özden
dc.institutionauthorSercan, Mustafa
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectTNF-alpha Blockersen_US
dc.subjectDepressionen_US
dc.subjectAnxietyen_US
dc.subjectQuality of Lifeen_US
dc.subjectCytokinesen_US
dc.titleThe effect of TNF-alpha blockers on psychometric measures in ankylosing spondylitis patients: a preliminary observationen_US
dc.typeArticleen_US

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