Serum uric acid is a determinant of metabolic syndrome in a population-based study

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dc.authorid0000-0002-5545-8874en_US
dc.authorid0000-0002-2001-9142en_US
dc.authorid0000-0001-9931-5456
dc.contributor.authorOnat, Altan
dc.contributor.authorUyarel, Hüseyin
dc.contributor.authorHergenç, Gülay
dc.contributor.authorKarabulut, Ahmet
dc.contributor.authorAlbayrak, Sinan
dc.contributor.authorSarı, İbrahim
dc.contributor.authorYazıcı, Mehmet
dc.date.accessioned2021-06-23T19:18:50Z
dc.date.available2021-06-23T19:18:50Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Determination of serum uric acid concentrations and role in risk of metabolic syndrome (MS) were investigated in 1877 participants in a cross-sectional population-based study including a brief follow-up. Methods: The MS was identified by modified criteria of the Adult Treatment Panel III, and coronary heart disease (CHD) by clinical findings and Minnesota coding of resting electrocardiograms. Uric acid concentrations were measured by the uricase method. Results: Metabolic syndrome was present in 39.1% of the cohort. Linear regression analysis of uric acid levels in a model comprising 13 variables identified gender, waist girth, total cholesterol (TC), alcohol usage, triglycerides, log C-reactive protein (CRP), and log gamma-glutamyl transferase (GGT), and in women diuretic use and elevated blood pressure (BP), as significant independent covariates whereby the largest contribution (1.6 mg/dL) was generated by waist girth. Logistic regression analysis of serum uric acid for MS disclosed for the top versus the bottom tertile an odds ratio (OR) of 1.89 (95% confidence interval [CI]: 1.45-2.46) in men and women combined, after ajustment for sex, age, TC, log CRP, log GGT, alcohol, and diuretic drug use, presence of diabetes/impaired fasting glucose, elevated BP, and smoking status. This corresponded to an increase by 35% in MS likelihood for each 1 SD uric acid increment. This rate declined to a significant 15% by inclusion of waist girth into the model. The OR of uric acid concentrations for prevalent and incident CHD, adjusted for age, MS, smoking, and diuretic use, was not significant among women and only tended toward significance in men. Conclusions: Abdominal obesity is the main determinant of uric acid variance. An increment of 1 SD in serum uric acid levels are associated in both sexes with a 35% higher MS likelihood, independent of 10 risk factors related to MS. After adjustment for waist girth, a more modest but significant likelihood persists, which suggests that serum uric acid is a determinant of MS.en_US
dc.identifier.doi10.1016/j.amjhyper.2006.02.014
dc.identifier.endpage1062en_US
dc.identifier.issn0895-7061
dc.identifier.issn1941-7225
dc.identifier.issue10en_US
dc.identifier.pmid17027827en_US
dc.identifier.scopus2-s2.0-33749260511en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1055en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjhyper.2006.02.014
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5820
dc.identifier.volume19en_US
dc.identifier.wosWOS:000241745400014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAlbayrak, Sinan
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofAmerican Journal Of Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAbdominal Obesityen_US
dc.subjectCoronary Heart Disease Risken_US
dc.subjectHypertensionen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectPopulation-based Studyen_US
dc.subjectSerum Uric Aciden_US
dc.titleSerum uric acid is a determinant of metabolic syndrome in a population-based studyen_US
dc.typeArticleen_US

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