Effects of neurotensin on the healing of experimental anastomosis of the colon

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dc.authorid0000-0003-4630-9516
dc.authorid0000-0003-2769-253X
dc.authorid0000-0001-8083-3835
dc.authorid0000-0002-6708-7679
dc.contributor.authorGürleyik, Günay Meryem
dc.contributor.authorGürleyik, Emin
dc.contributor.authorYılmazcan, Ali
dc.contributor.authorÖzcan, Ayhan
dc.contributor.authorOnaran, İlhan
dc.contributor.authorÜnalmiŝer, Selçuk
dc.date.accessioned2021-06-23T18:54:51Z
dc.date.available2021-06-23T18:54:51Z
dc.date.issued2002
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThe leakage of colonic anastomoses increases perioperative morbidity significantly. The purpose of the study was to investigate the influence of neurotensin, an intestinal trophic peptide, on the healing of colonic anastomosis. Forty-two Wistar-albino rats were separated into three equal groups : Group 1 (control group) - segmental resection of the left colon and end-to-end anastomosis ; Group 2 (dexamethasone group) - resection and anastomosis, plus 0.1 mg/kg/day of dexamethasone ; Group 3 (neurotensin group) - same surgical procedure plus 300 ?g/kg/day of neurotensin. Bursting pressure and tissue hydroxyproline content were determined as parameters of the anastomosis strength and healing on the 3rd and 7th days postoperatively. On the 3rd day, mean bursting pressures were 141.4, 146.7 and 73.1 (p = 0.0001) cm of water in the control group, dexamethasone and neurotensin groups respectively. On the 7th day, bursting pressures were measured as 237.4, 100.6 (p = 0.0001) and 72.7(p = 10-6) cm of water, in the control group, dexamethasone and neurotensin groups respectively. Between the 3rd and 7th days, bursting pressures were increased significantly in the control group (p = 0.0001), decreased in the dexamethasone (p = 0.048), and maintained their lowest values in the neurotensin (p = 0.96) groups. On the 7th day, mean hydroxyproline levels were measured as 9.20, 3.30 (p = 0.007), 2.86 (p = 0.007) ?g, in the control group, dexamethasone. and neurotensin groups respectively. Between the 3rd and 7th days, tissue hydroxyproline levels were increased significantly in the control group (p = 0.004), decreased in the dexamethasone (p = 0.03), and maintained their lowest values in the neurotensin (p = 0.87) groups. The anastomosis resistance to intraluminal pressure was weak, tissue collagen content was insufficient, and healing was inadequate in the dexamethasone and neurotensin groups in respect to the control group. We concluded that neurotensin impaired the healing, and affected the strength of the colonic anastomosis.en_US
dc.identifier.doi10.1080/00015458.2002.11679260
dc.identifier.endpage36en_US
dc.identifier.issn0001-5458
dc.identifier.issue1en_US
dc.identifier.pmid11925737en_US
dc.identifier.scopus2-s2.0-0036480486en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage33en_US
dc.identifier.urihttps://doi.org/10.1080/00015458.2002.11679260
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4599
dc.identifier.volume102en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGürleyik, Günay Meryem
dc.institutionauthorGürleyik, Emin
dc.institutionauthorYılmazcan, Ali
dc.institutionauthorÜnalmiŝer, Selçuk
dc.language.isoenen_US
dc.publisherARSMB-KVBMGen_US
dc.relation.ispartofActa Chirurgica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnastomosisen_US
dc.subjectBursting pressureen_US
dc.subjectCorticosteroiden_US
dc.subjectHydroxyprolineen_US
dc.subjectLarge Bowelen_US
dc.subjectNeurotensinen_US
dc.titleEffects of neurotensin on the healing of experimental anastomosis of the colonen_US
dc.typeArticleen_US

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