Effects of long term oral acrylamide administration on alpha naphthyl acetate esterase and acid phosphatase activities in the peripheral blood lymphocytes of rats

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dc.authorid0000-0002-3344-6637
dc.authorid0000-0002-3587-7609
dc.authorid0000-0002-3513-7424
dc.authorid0000-0002-6296-3107
dc.authorid0000-0002-4552-5658
dc.contributor.authorYener, Yeşim
dc.contributor.authorÇelik, İlhami
dc.contributor.authorSur, Emrah
dc.contributor.authorÖznurlu, Yasemin
dc.contributor.authorÖzaydın, Tuğba
dc.date.accessioned2021-06-23T19:51:18Z
dc.date.available2021-06-23T19:51:18Z
dc.date.issued2019
dc.departmentBAİBÜ, Eğitim Fakültesi, Temel Eğitim Bölümüen_US
dc.description.abstractAcrylamide is an important industrial chemical; it also is formed in starch-rich foodstuffs during baking, frying and roasting. Most acrylamide exposure occurs by ingestion of processed foods. We investigated possible immunotoxic effects of extended administration of low doses of acrylamide in rats. To do this, we measured alpha-naphthyl acetate esterase (ANAE) and acid phosphatase (ACP-ase) activities in peripheral blood lymphocytes. Male and female weanling Wistar rats were administered 2 or 5 mg acrylamide/kg/day in drinking water for 90days. Peripheral blood was sampled at the end of the administration period. We found ANAE staining in eosinophils and T-lymphocytes, but not in monocytes, platelets, B-lymphocytes and neutrophils. ACP-ase was found in B-lymphocytes. We found a significant reduction of the ratio of ANAE:ACP-ase in lymphocytes of the experimental animals compared to controls. We found no statistically significant differences between the doses or sexes. We found that acrylamide ingested in processed foods might affect the immune system adversely by decreasing the population of mature T- and B-lymphocytes.en_US
dc.identifier.doi10.1080/10520295.2019.1571227
dc.identifier.endpage359en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5en_US
dc.identifier.pmid30864862en_US
dc.identifier.scopus2-s2.0-85062938911en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage352en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1571227
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9963
dc.identifier.volume94en_US
dc.identifier.wosWOS:000482264200008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYener, Yeşim
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcid Phosphataseen_US
dc.subjectAcrylamideen_US
dc.subjectAlpha-naphthyl Acetate Esteraseen_US
dc.subjectBlooden_US
dc.subjectEnzyme Histochemistryen_US
dc.subjectLymphocytesen_US
dc.subjectRatsen_US
dc.titleEffects of long term oral acrylamide administration on alpha naphthyl acetate esterase and acid phosphatase activities in the peripheral blood lymphocytes of ratsen_US
dc.typeArticleen_US

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