Severe cutaneous adverse drug reactions in pediatric patients: a multicenter study

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dc.authorid0000-0001-7659-5221en_US
dc.authorid0000-0002-3241-2005
dc.authorid0000-0003-4298-6851
dc.authorid0000-0002-1258-9348
dc.contributor.authorMısırlıoğlu, Emine Dibek
dc.contributor.authorGüvenir, Hakan
dc.contributor.authorBahçeci, Semiha
dc.contributor.authorAbul, Mehtap Haktanır
dc.contributor.authorCan, Demet
dc.contributor.authorErkoçoğlu, Mustafa
dc.date.accessioned2021-06-23T19:48:54Z
dc.date.available2021-06-23T19:48:54Z
dc.date.issued2017
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND: The severe cutaneous adverse drug reactions (SCARs) are rare but could be life-threatening. These include drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis. OBJECTIVE: The purpose of this study was the evaluation of the clinical characteristics of patients with the diagnosis of SCARs. METHODS: Patients who were diagnosed with SCARs between January 2011 and May 2016 by pediatric allergy clinics in the provinces of Ankara, Trabzon, Izmir, Adana, and Bolu were included in this multicenter study. Clinical and laboratory findings, the time between suspected drug intake and development of clinical findings, treatments they have received, and length of recovery time were recorded. RESULTS: Fifty-eight patients with SCARs were included in this study. The median age of the patients was 8.2 years (interquartile range, 5.25-13 years) and 50% (n = 29) were males. Diagnosis was Stevens-Johnson syndrome/TEN in 60.4% (n = 35), DRESS in 27.6% (n = 16), and acute generalized exanthematous pustulosis in 12% (n = 7) of the patients. In 93.1% of the patients, drugs were the cause of the reactions. Antibiotics ranked first among the drugs (51.7%) and antiepileptic drugs were the second (31%) most common. A patient who was diagnosed with TEN developed lagophthalmos and a patient who was diagnosed with DRESS developed secondary diabetes mellitus. Only 1 patient with the diagnosis of TEN died. CONCLUSIONS: SCARs in children are not common but potentially serious. Early diagnosis and appropriate treatment of SCARs will reduce the incidence of morbidity and mortality. (C) 2017 American Academy of Allergy, Asthma & Immunologyen_US
dc.identifier.doi10.1016/j.jaip.2017.02.013
dc.identifier.endpage763en_US
dc.identifier.issn2213-2198
dc.identifier.issn2213-2201
dc.identifier.issue3en_US
dc.identifier.pmid28351788en_US
dc.identifier.scopus2-s2.0-85016030882en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage757en_US
dc.identifier.urihttps://doi.org/10.1016/j.jaip.2017.02.013
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9240
dc.identifier.volume5en_US
dc.identifier.wosWOS:000405923700029en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErkoçoğlu, Mustafa
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal Of Allergy And Clinical Immunology-In Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Generalized Exanthematous Pustulosisen_US
dc.subjectChildrenen_US
dc.subjectDressen_US
dc.subjectEosinophiliaen_US
dc.subjectStevens-Johnson Syndromeen_US
dc.subjectSevere Cutaneous Adverse Drug Reactionsen_US
dc.subjectToxic Epidermal Necrolysisen_US
dc.titleSevere cutaneous adverse drug reactions in pediatric patients: a multicenter studyen_US
dc.typeArticleen_US

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