Lack of an effect of CYP3A4 and MDR1 gene polymorphisms on colchicine pharmacogenetics in the treatment of familial Mediterranean fever

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dc.authorid0000-0002-2408-5294en_US
dc.authorid0000-0003-1710-7018en_US
dc.contributor.authorDoğruer, D.
dc.contributor.authorTuğ, Esra
dc.contributor.authorBes, Cemal
dc.contributor.authorSoy, Mehmet
dc.date.accessioned2021-06-23T19:34:55Z
dc.date.available2021-06-23T19:34:55Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe P-gp/MDR1 multidrug transporter mediates detoxification of numerous drugs, including colchicine, and CYP3A4 is key to the biotransformation of colchicine. We investigated the effects of CYP3A4 and P-gp/MDR1 polymorphisms on bioavailability of colchicine in patients with Familial Mediterranean fever (FMF). Forty-eight Turkish patients with FMF treated with colchicine were genotyped for 3435C>T, (-)1A>G, 61A>G, 1199G>A, 1236C>T, 2677G>A, 2677G>T polymorphisms in the P-gp/MDR1 gene and 3435C>T, *1B(-392A>G), *2(15713T>C), *3(23171T>C), *12(21896C>T), *17(15615T>C) polymorphisms in the CYP3A4 gene. Doses of colchicine administered to patients did not differ with respect to P-gp/MDR1 or CYP3A4 gene polymorphism. We also determined the genotype distributions of CYP3A4 and P-gp/MDR1 genes among FMF patients. There was no significant gender difference in the P-gp/MDR1 polymorphism, whereas there were significant gender differences in the frequencies of 15713T>C and 15615T>C polymorphisms in the CYP3A4 gene. No significant relationship was found between colchicine doses that would introduce optimal clinical response and affect the therapeutic dose and CYP3A4 and P-gp/MDR1 gene polymorphisms in these FMF patients.en_US
dc.identifier.doi10.4238/2013.January.24.2
dc.identifier.endpage3528en_US
dc.identifier.issn1676-5680
dc.identifier.issue3en_US
dc.identifier.pmid23408444en_US
dc.identifier.scopus2-s2.0-84884573185en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage3521en_US
dc.identifier.urihttps://doi.org/10.4238/2013.January.24.2
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7662
dc.identifier.volume12en_US
dc.identifier.wosWOS:000331717400143en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDoğruer, D.
dc.institutionauthorTuğ, Esra
dc.institutionauthorBes, Cemal
dc.institutionauthorSoy, Mehmet
dc.language.isoenen_US
dc.publisherFunpec-Editoraen_US
dc.relation.ispartofGenetics And Molecular Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColchicineen_US
dc.subjectP-gp/MDR1en_US
dc.subjectCYP3A4en_US
dc.subjectPharmacogeneticsen_US
dc.subjectFamilial Mediterranean feveren_US
dc.titleLack of an effect of CYP3A4 and MDR1 gene polymorphisms on colchicine pharmacogenetics in the treatment of familial Mediterranean feveren_US
dc.typeArticleen_US

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