The effects of pinealectomy, melatonin injections and implants on the spatial memory performance of male Wistar rats

Basit Öğe Kaydı
dc.authorid000-0002-5509-8717
dc.contributor.authorKarakaş, Alper
dc.contributor.authorCoşkun, Hamit
dc.contributor.authorKaya, Aliye
dc.date.accessioned2021-06-23T19:28:30Z
dc.date.available2021-06-23T19:28:30Z
dc.date.issued2011
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractMelatonin is the main hormone of the pineal gland that informs the body about the environmental light and darkness regimen and is considered to regulate many important physiological and behavioural activities. In the present study, we examined the effects of pinealectomy, constant-release melatonin implants and timed melatonin injections on spatial memory in male Wistar rats by using Morris water maze. Pinealectomy, melatonin injection and melatonin implantation were performed on groups, including controls for all groups. After a week of the pinealectomy and melatonin implantation surgeries, we applied the injections and made the training trials throughout 4 days. At the fifth day, experiments were performed and recorded. Spatial memory performance of the rats was impaired by the pinealectomy and melatonin injections, since they elongated the latency and shortened the time passed in the correct quadrant. Melatonin implantation did not affect the spatial memory performance of the rats. The latency and the time passed in correct quadrant were not statistically different from their controls. The results suggest that while the removal of the pineal gland and exogenous administration of melatonin via injections are causing impairment, constant-release melatonin administration via implantation does not affect the spatial memory in Wistar albino rats.en_US
dc.identifier.doi10.1080/09291016.2010.537443
dc.identifier.endpage472en_US
dc.identifier.issn0929-1016
dc.identifier.issn1744-4179
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-79955754771en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.1080/09291016.2010.537443
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7027
dc.identifier.volume42en_US
dc.identifier.wosWOS:000299786900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKarakaş, Alper
dc.institutionauthorCoşkun, Hamit
dc.institutionauthorKaya, Aliye
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiological Rhythm Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectPinealectomyen_US
dc.subjectMorris Water Mazeen_US
dc.subjectMemoryen_US
dc.titleThe effects of pinealectomy, melatonin injections and implants on the spatial memory performance of male Wistar ratsen_US
dc.typeArticleen_US

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