Effects of topical mitomycin on inner ear: A light and electron microscopic study

dc.authorid0000-0002-8084-7855
dc.contributor.authorÇankaya, Hakan
dc.contributor.authorEgeli, Erol
dc.contributor.authorKuntsal, Leyla
dc.contributor.authorÖzbek, Hanifi
dc.contributor.authorİçli, Murat
dc.date.accessioned2021-06-23T18:54:49Z
dc.date.available2021-06-23T18:54:49Z
dc.date.issued2002
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractProviding maintenance of myringotomy patency without use of ventilation tubes in the treatment of secretory otitis media has been one of the important study areas. For this reason, laser and Mitomycin C (MMC) are used together in experimental studies. But there has been no ultrastructural studies concerning whether leakage of MMC to middle ear during application of this procedure has an ototoxic effect or not and if so, to what extent. In this study, we searched the ultrastructural changes which occurred in the middle ear by direct applications of MMC to the middle ear for different time durations. The study was carried out over thirty adult guinea pigs without ear diseases. Bilateral myringotomy was performed and MMC was applied only to the right middle ear of each guinea pig. The first group received MMC once for 10 minutes, the second group received it once for 20 minutes, and the third group took it each day for 10 minutes during a one week period. The left ears of the samples were accepted as the control group. On the 8th day, sacrification was carried out. After electron and light microscopy examination, significant changes in the inner ear were observed in the third group though no significant change was observed for the first and the second groups. As a result it was concluded that the application of MMC to the middle ear once for a short duration causes no toxic effect on the inner ear. © 2002 Tohoku University Medical Press.en_US
dc.identifier.doi10.1620/tjem.197.81
dc.identifier.endpage86en_US
dc.identifier.issn0040-8727
dc.identifier.issue2en_US
dc.identifier.pmid12233787en_US
dc.identifier.scopus2-s2.0-0036622899en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.197.81
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4589
dc.identifier.volume197en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEgeli, Erol
dc.language.isoenen_US
dc.relation.ispartofTohoku Journal of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInner earen_US
dc.subjectMitomycinen_US
dc.subjectMyringotomyen_US
dc.subjectOtotoxicityen_US
dc.subjectSecretory Otitis Mediaen_US
dc.titleEffects of topical mitomycin on inner ear: A light and electron microscopic studyen_US
dc.typeArticleen_US

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