Investigation of the impact of antiparasitic drug moxidectin on the rewarding effects of alcohol

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dc.authorid0000-0001-6034-513Xen_US
dc.authorid0000-0003-4219-8054en_US
dc.authorid0000-0002-2134-6196en_US
dc.authorid0000-0001-5124-7853en_US
dc.authorid0000-0003-1075-9574en_US
dc.contributor.authorEkici, Abdurrahman
dc.contributor.authorGürbüz, Esra
dc.contributor.authorBerköz, Mehmet
dc.contributor.authorTürkmen, Ömer
dc.contributor.authorBaşbuğan, Yıldıray
dc.contributor.authorYunusoğlu, Oruç
dc.date.accessioned2023-07-28T10:44:02Z
dc.date.available2023-07-28T10:44:02Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAlcohol addiction or alcoholism constitutes a significant risk factor worldwide for morbidity and mortality. Moxidectin is a recently approved anthelmintic drug, which also activates the gamma-aminobutyric acid receptors. The objective of the present study was to examine the impact of moxidectin on rewarding effects of ethanol in the conditioned place preference (CPP) model in mice. In separate experiments, mice were administered intraperitoneal (i.p.) injections of moxidectin (5 or 10 mg/kg) before a) acquisition of alcohol-induced CPP, b) each extinction session, and c) alcohol-induced reinstatement of CPP. The present experiments provide consistent data about ethanol place preference in mice (2 g/kg, i.p.), with mice in all tests spending significantly more time on the ethanol-paired side. The acquisition of the CPP response to ethanol was prevented by the administration of moxidectin at a dose of 10 mg/kg. Additionally, moxidectin treatment accelerated the extinction of ethanol CPP when given repeatedly during the extinction phase. Ethanol-induced reinstatement of CPP following an extinction phase was inhibited by moxidectin. Ethanol alone and co-administration with moxidectin did not change locomotor activity and motor coordination. In conclusion, we suggest that moxidectin may be a promising therapeutic candidate for prevention of ethanol-induced addiction and relapse as well as detoxification.en_US
dc.identifier.citationEkici, A., Gürbüz, E., Berköz, M., Türkmen, Ö., Başbuğan, Y., & Yunusoğlu, O. (2022). Investigation of the impact of antiparasitic drug moxidectin on the rewarding effects of alcohol. General Physiology & Biophysics, 41(3).en_US
dc.identifier.doi10.4149/gpb_2022014
dc.identifier.endpage253en_US
dc.identifier.issn0231-5882
dc.identifier.issn1338-4325
dc.identifier.issue3en_US
dc.identifier.pmid35616004en_US
dc.identifier.scopus2-s2.0-85131106550en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage245en_US
dc.identifier.urihttp://dx.doi.org/10.4149/gpb_2022014
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11394
dc.identifier.volume41en_US
dc.identifier.wosWOS:000874381500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYunusoğlu, Oruç
dc.language.isoenen_US
dc.publisherAepress Sroen_US
dc.relation.ispartofGeneral Physiology and Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlcohol Addictionen_US
dc.subjectMoxidectinen_US
dc.subjectConditioned Place Preferenceen_US
dc.subjectMiceen_US
dc.subjectConditioned Place Preferenceen_US
dc.subjectSex-Differenceen_US
dc.titleInvestigation of the impact of antiparasitic drug moxidectin on the rewarding effects of alcoholen_US
dc.typeArticleen_US

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