The inhibitory role of melatonin on isolated guinea-pig urinary bladder: an endogenous hormone effect

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dc.authorid0000-0001-8688-4772en_US
dc.authorid0000-0002-7827-4840en_US
dc.authorid0000-0001-6235-0389en_US
dc.authorid0000-0002-9449-9564
dc.contributor.authorSemerciöz, Atilla
dc.contributor.authorOnur, Rahmi
dc.contributor.authorAyar, Ahmet
dc.contributor.authorOrhan, İrfan
dc.date.accessioned2021-06-23T19:17:46Z
dc.date.available2021-06-23T19:17:46Z
dc.date.issued2004
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE To investigate the effects of melatonin, an endogenous hormone, on acetylcholine and KCl-induced contractions of isolated guinea-pig detrusor muscle. MATERIALS AND METHODS Detrusor smooth muscle strips isolated from guinea-pig bladders were placed in an organ bath containing physiological saline at 37 degreesC and pH 7.4, constantly bubbled with 95% oxygen and 5% CO2. The effects of cumulatively applied melatonin on the acetylcholine- and KCl-induced contractions of isolated bladder strips were examined using isometric contraction measurements. RESULTS Melatonin (100 and 300 mumol/L) significantly inhibited the peak amplitude of both acetylcholine (10 mumol/L) and KCl (30 mmol/L)-induced contraction of the isolated bladder strips (P < 0.05). Similarly, melatonin caused a significant reduction in the contractile frequency induced by KCl (eight strips) in a concentration-dependent manner, while having no significant effect on the frequency of contractile response to acetylcholine, even at the highest concentration (300 mu mol/L) used (P = 0.58, 14 strips). CONCLUSIONS These results suggest that melatonin inhibits acetylcholine- and KCl-induced contractions in isolated bladder strips from guinea pigs. The endogenous nature of melatonin, with its low side-effect profile, makes it a potentially useful agent to be considered in the medical management of the overactive bladder.en_US
dc.identifier.doi10.1111/j.1464-410X.2004.05175.x
dc.identifier.endpage1376en_US
dc.identifier.issn1464-4096
dc.identifier.issue9en_US
dc.identifier.pmid15610123en_US
dc.identifier.scopus2-s2.0-11144241108en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1373en_US
dc.identifier.urihttps://doi.org/10.1111/j.1464-410X.2004.05175.x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5536
dc.identifier.volume94en_US
dc.identifier.wosWOS:000226256100040en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSemerciöz, Atilla
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBju Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladderen_US
dc.subjectDetrusoren_US
dc.subjectContractionen_US
dc.subjectMelatoninen_US
dc.subjectInhibitionen_US
dc.titleThe inhibitory role of melatonin on isolated guinea-pig urinary bladder: an endogenous hormone effecten_US
dc.typeArticleen_US

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