Effects of combined pulse electromagnetic field stimulation plus glutamine on the healing of colonic anastomosis in rats

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dc.authorid0000-0002-1194-6649en_US
dc.authorid0000-0001-5608-5742
dc.authorid0000-0003-1218-4962
dc.contributor.authorGirgin, Sadullah
dc.contributor.authorGedik, Ercan
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorAkbulut, Veysi
dc.contributor.authorKale, Ebru
dc.date.accessioned2021-06-23T19:26:18Z
dc.date.available2021-06-23T19:26:18Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose An experimental study was designed to investigate the effect of combined pulse electromagnetic field (PEMF) stimulation plus glutamine administration on colonic anastomosis. Methods Anastomosis of the left colon was performed in 28 rats, which were divided into four groups; Group 1: normal resection anastomosis plus oral 50 mg/kg/day glutamine; Group 2: normal resection anastomosis plus PEMF stimulation plus oral 50 mg/kg/day glutamine; Group 3: normal resection anastomosis plus PEMF stimulation; Group 4: normal resection anastomosis. On the seventh postoperative day, the animals were killed and the bursting pressure and tissue hydroxyproline concentration of the anastomosis were analyzed and compared. Results The mean anastomotic bursting pressure in Group 2 was significantly higher than in Groups 1 and 4. On the other hand, the mean anastomotic bursting pressure in Group 1 was significantly higher than in Group 4. The collagen deposition and the fibroblast infiltration were significantly increased on the seventh day in Group 3 compared the other groups. On the other hand, Groups 1 and 2 had higher scores for collagen deposition and fibroblast infiltration than Group 4. Conclusions In conclusion, burst pressures, hydroxyproline, and histologic features (fibroblast infiltration and collagen deposition) were improved in the PEMF group, and both PEMF and glutamine-enriched nutrition provide a significant gain in the strength of colonic anastomoses in rats.en_US
dc.identifier.doi10.1007/s10620-008-0412-x
dc.identifier.endpage750en_US
dc.identifier.issn0163-2116
dc.identifier.issn1573-2568
dc.identifier.issue4en_US
dc.identifier.pmid18649133en_US
dc.identifier.scopus2-s2.0-63249124519en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage745en_US
dc.identifier.urihttps://doi.org/10.1007/s10620-008-0412-x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6496
dc.identifier.volume54en_US
dc.identifier.wosWOS:000263832600008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖztürk, Hayrettin
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofDigestive Diseases And Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPulse Electromagnetic Fielden_US
dc.subjectGlutamineen_US
dc.subjectColonic Anastomosisen_US
dc.titleEffects of combined pulse electromagnetic field stimulation plus glutamine on the healing of colonic anastomosis in ratsen_US
dc.typeArticleen_US

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