Effects of bone marrow and adipose-derived mesenchymal stem cells on microRNA expressions in acute alkaline corneal burn

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dc.authorid0000-0003-3462-1502en_US
dc.authorid0000-0002-2876-055Xen_US
dc.authorid0000-0003-2940-3172en_US
dc.authorid0000-0003-4216-0814en_US
dc.authorid0000-0002-9630-3852en_US
dc.authorid0000-0003-2020-4417en_US
dc.contributor.authorDinç, Erdem
dc.contributor.authorAyaz, Lokman
dc.contributor.authorKurt, Akif Hakan
dc.contributor.authorDursun, Özer
dc.contributor.authorYılmaz, Gülşen
dc.contributor.authorVatansever, Mustafa
dc.date.accessioned2023-07-03T11:58:39Z
dc.date.available2023-07-03T11:58:39Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: The aim of this study was to investigate the microRNA (miRNA) expressions of the corneal tissue after an alkaline burn and to compare the efficiency of adipose- and bone marrow-derived mesenchymal stem cells (MSCs) on expressions. Methods: Thirty-two rats were divided into 4 groups. No intervention was made in the control group. A chemical burn was created by applying 4 mu L NaOH soaked in 6 mm filter paper to the right eye of each animal in the other groups. Whereas only subconjunctival 0.1 mL phosphate-buffered saline (PBS) was injected to in the group 1, 2 x 10(6) adipose- or bone marrow-derived MSC in 0.1 mL PBS was injected subconjunctivally to the animals in the remaining groups (groups 2 and 3, respectively). Tissue samples were collected for miRNA analysis on the third day after the burn. Results: When group 1 was compared with the control group, the expression of 3 of 93 miRNAs increased significantly, whereas the expression of 50 miRNAs decreased significantly. Significant changes in miRNA expressions were observed when group 1 was compared with groups 2 and 3. Although a significant change was observed in the expression of 6 miRNAs in the adipose-derived MSC group, it was found that the expression of 65 miRNAs significantly changed in the bone marrow-derived MSC group. Conclusion: This study shows that there are significant changes in some miRNA expressions after corneal alkaline burn and these changes can be reversed with the subconjunctival injection of MSCs.en_US
dc.identifier.citationDinç, E., Ayaz, L., Kurt, A. H., Dursun, Ö., Yılmaz, G., Vatansever, M., ... & Yılmaz, Ş. N. (2021). Effects of bone marrow and adipose-derived mesenchymal stem cells on microRNA expressions in acute alkaline corneal burn. Journal of Ocular Pharmacology and Therapeutics, 37(4), 200-208.en_US
dc.identifier.doi10.1089/jop.2020.0107
dc.identifier.endpage208en_US
dc.identifier.issn1080-7683
dc.identifier.issn1557-7732
dc.identifier.issue4en_US
dc.identifier.pmid33481657en_US
dc.identifier.scopus2-s2.0-85105719007en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage200en_US
dc.identifier.urihttp://dx.doi.org/10.1089/jop.2020.0107
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11226
dc.identifier.volume37en_US
dc.identifier.wosWOS:000648085500003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKurt, Akif Hakan
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Inc.en_US
dc.relation.ispartofJournal of Ocular Pharmacology and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlkaline Corneal Burnen_US
dc.subjectMesenchymal Stem Cellen_US
dc.subjectMirnaen_US
dc.subjectChemical Burnen_US
dc.subjectPBSen_US
dc.titleEffects of bone marrow and adipose-derived mesenchymal stem cells on microRNA expressions in acute alkaline corneal burnen_US
dc.typeArticleen_US

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