Transgenerational effects of periconception heavy metal administration on adipose weight and glucose homeostasis in mice at maturity

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dc.authorid0000-0001-6450-7773en_US
dc.authorid0000-0002-6674-5932
dc.contributor.authorÇamsarı, Çağrı
dc.contributor.authorFolger, Joseph K.
dc.contributor.authorRajput, Sandeep K.
dc.contributor.authorMcGee, Devin
dc.contributor.authorLatham, Keith E.
dc.contributor.authorSmith, George W.
dc.date.accessioned2021-06-23T19:51:54Z
dc.date.available2021-06-23T19:51:54Z
dc.date.issued2019
dc.departmentBAİBÜ, Rektörlük, Yenilikçi Gıda Teknolojileri Geliştirme Uygulama ve Araştırma Merkezien_US
dc.description.abstractWe previously demonstrated that periconception maternal administration (2 mg/kg body weight each) of cadmium chloride (CdCl2) plus methylmercury (II) chloride (CH3HgCl) impaired glucose homeostasis and increased body weights and abdominal adipose tissue weight of male offspring in the F1 generation. However, transgenerational effects of this exposure have not been studied. Therefore, the effects of periconception Cd+Hg administration on indices of chronic diseases at adulthood in F2-F4 generations were examined. Male and female progeny of Cd+Hg periconceptionally treated females, and offspring of vehicle control females were bred with naive CD1 mice to obtain F2 offspring, with additional crosses as above to the F4 generation (F1-F4 animals were not administered Cd+Hg). Birth weights and litter size were similar in all generations. Indices of impaired glucose homeostasis were observed in matrilineally descended F2 male offspring, including reduced glucose tolerance, along with increased basal phosphorylation of insulin receptor substrate 1 (IRS1) at serine 307 suggesting altered insulin signaling. Reduced glucose tolerance was also seen in F4 males. Increased body weight and/or abdominal adiposity were observed through the F4 generation in males descended matrilineally from the treated female progenitors. Patrilineally derived F2 females displayed reduced glucose tolerance. Females (F2) patrilineally and matrilineally derived displayed significant kidney enlargement. Periconception administration of cadmium and mercury caused persistent transgenerational effects in offspring through the F4 generation in the absence of continued toxicant exposure, with persistent transgenerational effects inherited specifically through the matrilineal germline.en_US
dc.identifier.doi10.1093/toxsci/kfz008
dc.identifier.endpage619en_US
dc.identifier.issn1096-6080
dc.identifier.issn1096-0929
dc.identifier.issue2en_US
dc.identifier.pmid30629257en_US
dc.identifier.scopus2-s2.0-85063713020en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage610en_US
dc.identifier.urihttps://doi.org/10.1093/toxsci/kfz008
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10065
dc.identifier.volume168en_US
dc.identifier.wosWOS:000465223200026en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇamsarı, Çağrı
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofToxicological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTransgenerational Effecten_US
dc.subjectPericonception Administrationen_US
dc.subjectCadmiumen_US
dc.subjectMercuryen_US
dc.subjectSexual Dimorphismen_US
dc.subjectMetabolic Syndromeen_US
dc.titleTransgenerational effects of periconception heavy metal administration on adipose weight and glucose homeostasis in mice at maturityen_US
dc.typeArticleen_US

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