Serum sclerostin levels in chronic otitis media with and without cholesteatoma

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dc.authorid0000-0002-8164-4056en_US
dc.authorid0000-0002-7006-3125
dc.contributor.authorKaralı, Elif
dc.contributor.authorYis,Özgür Mehmet
dc.date.accessioned2021-06-23T19:54:05Z
dc.date.available2021-06-23T19:54:05Z
dc.date.issued2020
dc.description.abstractOBJECTIVE: Sclerostin is a glycoprotein that plays a catabolic role in bone and is involved in the regulation of bone metabolism by increasing the osteoclastic bone resorption. In this study, serum sclerostin levels were measured in chronic otitis media (COM) with and without cholesteatoma, assuming that it might have a role in the aetiopathogenesis of bone resorption. METHODS: A total of 44 patients with cholesteatomatous COM (cCOM) (n = 22) and non-cholesteatomatous COM (ncCOM) (n = 22) were included in this study, and 26 healthy volunteers without any chronic ear disease problem(s) constituted the control group (n =26). RESULTS: No significant difference was not found in terms of serum iPTH, ALP, and vitamin D levels between ncCOM, cCOM, and the control groups. A significant difference was found in terms of serum sclerostin, Ca, and P levels between ncCOM, cCOM, and the control groups (p<0.05). Serum sclerostin levels in the study groups were significantly higher but their serum Ca and P levels were significantly lower compared to the control group. CONCLUSION: We think that serum sclerostin concentrations, which were significantly higher in patients with cCOM and ncCOM compared to healthy controls are associated with bone erosion. There is a need for further studies with larger samples in order to determine the relationship between sclerostin and bone erosion in cholesteatoma to help in establishing preventive measures against cholesteatoma and set new targets for the development of non-surgical treatments.en_US
dc.identifier.doi10.1590/1806-9282.66.7.966
dc.identifier.endpage972en_US
dc.identifier.issn1806-9282
dc.identifier.issue7en_US
dc.identifier.pmid32844952en_US
dc.identifier.scopus2-s2.0-85089928121en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage966en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.66.7.966
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10414
dc.identifier.volume66en_US
dc.identifier.wosWOS:000562623600022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaralı, Elif
dc.institutionauthorYis, Özgür Mehmet
dc.language.isoenen_US
dc.publisherAssoc Medica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOtitis Mediaen_US
dc.subjectCholesteatomaen_US
dc.subjectEar, Middleen_US
dc.subjectBone Morphogenetic Proteinsen_US
dc.titleSerum sclerostin levels in chronic otitis media with and without cholesteatomaen_US
dc.typeArticleen_US

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