Modulation of xenobiotic metabolizing enzyme activities in rat liver by co-administration of morin, endosulfan, and 7,12-dimethylbenz[a]anthracene

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dc.authorid0000-0002-8754-2528
dc.authorid0000-0002-8317-7092
dc.authorid0000-0002-6949-9191
dc.contributor.authorSapmaz, Canan
dc.contributor.authorFırat, Tülin
dc.contributor.authorKükner, Aysel
dc.contributor.authorBozcaarmutlu, Azra
dc.date.accessioned2021-06-23T19:54:39Z
dc.date.available2021-06-23T19:54:39Z
dc.date.issued2020
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.description.abstractMorin is a flavonoid which is present in many plants. Endosulfan and 7,12-dimethylbenz[a]anthracene (DMBA) are toxic chemicals that humans are exposed to in their daily lives. In this study, the protective role of morin was investigated in endosulfan and DMBA treated rats. Eight groups, each comprising seven 2.5-month-old adult male Wistar rats (weighing 170-255 g), were used. Endosulfan, morin, and DMBA were administered individually or in combinations, at 5 mg/kg body weight (bw) (three times/week), 25 mg/kg bw (three times/week), and 30 mg/kg bw (once/week for three weeks) via oral gavage, respectively. On day 54 of the administration period, the rats were killed. DMBA + endosulfan co-administration significantly increased CYP1A1-, CYP1A2-, CYP2E-, and GST-associated activities in the rats compared to the control. DMBA + endosulfan + morin significantly increased CYP1A1, CYP1A2, CYP3A, and GST associated activities in the rats relative to the control. Histopathological studies were performed to investigate protective effects of morin on liver damage. The results indicated that DMBA + endosulfan treatment induced liver damage, and morin reduced this damage. These findings suggest that CYP1A, CYP3A, and GST enzyme activities participate in the protective mechanism of morin against endosulfan and DMBA induced toxicity.en_US
dc.identifier.doi10.1080/01480545.2018.1471089
dc.identifier.endpage21en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue1en_US
dc.identifier.pmid29772942en_US
dc.identifier.scopus2-s2.0-85047121575en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2018.1471089
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10609
dc.identifier.volume43en_US
dc.identifier.wosWOS:000506467400002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSapmaz, Canan
dc.institutionauthorFırat, Tülin
dc.institutionauthorKükner, Aysel
dc.institutionauthorBozcaarmutlu, Azra
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug And Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytochrome P450en_US
dc.subject7en_US
dc.subject12-dimethylbenz[a]anthraceneen_US
dc.subjectEndosulfanen_US
dc.subjectMorinen_US
dc.subjectRaten_US
dc.subjectXenobiotic Metabolizing Enzymeen_US
dc.titleModulation of xenobiotic metabolizing enzyme activities in rat liver by co-administration of morin, endosulfan, and 7,12-dimethylbenz[a]anthraceneen_US
dc.typeArticleen_US

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