Assessment of toxicity and oxidative dna damage of sodium hypochlorite, chitosan and propolis on fibroblast cells

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dc.authorid0000-0002-1773-9114
dc.contributor.authorAydın, Zeliha Uğur
dc.contributor.authorAkpınar, Kerem Engin
dc.contributor.authorHepokur, Ceylan
dc.contributor.authorErdönmez, Demet
dc.date.accessioned2021-06-23T19:50:01Z
dc.date.available2021-06-23T19:50:01Z
dc.date.issued2018
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Endodonti Ana Bilim Dalıen_US
dc.description.abstractThe objective of this study was to evaluate and compare the cytotoxicity and genotoxicity on human fibroblast cell lines of sodium hypochlorite (NaOCl), chitosan and propolis as root canal irrigating solutions. Human fibroblast cells were exposed to chitosan, propolis and NaOCl for 4 and 24 h. Cell viability was assessed by 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide, and oxidative DNA damage was assessed by determination of 8-hydroxydeoxyguanosine (8-OHdG) level with an ELISA kit. The data of cell cytotoxicity were analysed statistically using a test of one-way analysis of variance at a significance level of p < 0.05. In the NaOCI group, the 8-OHdG level was higher than in the chitosan group, but there was no statistical difference when compared with the other groups (p < 0.05). It was determined that the irrigation solutions were cytotoxic, depending on the dose and time. NaOCl was the most toxic solution after both 4and 24 h of exposure (p < 0.05). Chitosan and propolis may be alternatives to NaOCl for irrigation solutions, because they are both less toxic and produce less oxidative DNA damage.en_US
dc.identifier.doi10.1590/1807-3107bor-2018.vol32.0119
dc.identifier.issn1807-3107
dc.identifier.pmid30517428en_US
dc.identifier.scopus2-s2.0-85060259350en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1590/1807-3107bor-2018.vol32.0119
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9681
dc.identifier.volume32en_US
dc.identifier.wosWOS:000467760500020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAydın, Zeliha Uğur
dc.language.isoenen_US
dc.publisherSociedade Brasileira De Pesquisa Odontologicaen_US
dc.relation.ispartofBrazilian Oral Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChitosanen_US
dc.subjectPropolisen_US
dc.subjectSodium Hypochloriteen_US
dc.titleAssessment of toxicity and oxidative dna damage of sodium hypochlorite, chitosan and propolis on fibroblast cellsen_US
dc.typeArticleen_US

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