Elevated platelet distribution width and red cell distribution width are associated with autoimmune liver diseases

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dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0002-1351-8832en_US
dc.authorid0000-0001-6905-4494en_US
dc.contributor.authorUstaoğlu, Müge
dc.contributor.authorAktaş, Gülali
dc.contributor.authorAvcıoğlu, Ufuk
dc.contributor.authorBas, Berk
dc.contributor.authorBahçeci, Buğra Kaan
dc.date.accessioned2023-05-31T11:08:44Z
dc.date.available2023-05-31T11:08:44Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective Red blood cell distribution width (RDW) and platelet distribution width (PDW) are reported to be associated with inflammation. We aimed to determine the association between RDW and PDW with autoimmune liver disease (ALD). Material and methods We retrospectively analyzed 126 patients who were diagnosed with ALD. Sixty-nine healthy individuals represented the control group. Characteristics and laboratory parameters of the ALD patients and control subjects were compared. Results The aspartate transaminase (AST) (P < 0.001), alanine transaminase (ALT) (P < 0.001), C-reactive protein (CRP) (P < 0.001), RDW (P < 0.001) and PDW (P < 0.001) levels of the ALD group were significantly higher than those of the control subjects. RDW was significantly correlated with AST (r = 0.17, P = 0.02) and CRP (r = 0.19, P = 0.01) levels. Moreover, PDW was significantly correlated with AST (r = 0.23, P = 0.002), ALT (r = 0.23, P = 0.001) and CRP (r = 0.23, P = 0.001) levels. The sensitivity and specificity of RDW higher than 13.7% level were 76% and 62%, respectively [AUC: 0.74, P < 0.001, 95% confidence interval (CI): 0.67-0.81]. The sensitivity and specificity of PDW higher than 17.9% level were 80% and 71%, respectively (AUC: 0.85, P < 0.001, 95% CI: 0.79-0.90). The sensitivity and specificity of CRP higher than 2.9 U/l level were 92% and 85%, respectively (AUC: 0.91, P < 0.001, 95% CI: 0.86-0.95). Conclusion Our study demonstrates that RDW and PDW have considerable sensitivity and specificity in determining ALD.en_US
dc.identifier.citationUstaoglu, M., Aktas, G., Avcioglu, U., Bas, B., & Bahceci, B. K. (2021). Elevated platelet distribution width and red cell distribution width are associated with autoimmune liver diseases. European journal of gastroenterology & hepatology, 33(1S), e905-e908.en_US
dc.identifier.doi10.1097/MEG.0000000000002296
dc.identifier.endpageE908en_US
dc.identifier.issn0954-691X
dc.identifier.issn1473-5687
dc.identifier.pmid34643621en_US
dc.identifier.scopus2-s2.0-85122739815en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE905en_US
dc.identifier.urihttp://dx.doi.org/10.1097/MEG.0000000000002296
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11028
dc.identifier.volume33en_US
dc.identifier.wosWOS:000766011800122en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAktaş, Gülali
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofEuropean Journal of Gastroenterology & Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutoimmune Liver Diseasesen_US
dc.subjectHemogram Indicesen_US
dc.subjectPlatelet Distribution Widthen_US
dc.subjectHepatitisen_US
dc.subjectFibrosisen_US
dc.subjectInflammationen_US
dc.titleElevated platelet distribution width and red cell distribution width are associated with autoimmune liver diseasesen_US
dc.typeArticleen_US

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