The effect of protocatechuic acid on ovarian histopathology and reserve in rat ovarian torsion model

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dc.authorid0000-0001-5400-0012en_US
dc.authorid0000-0002-8212-7149en_US
dc.contributor.authorErimşah, Sevilay
dc.contributor.authorÇetinkaya, Ayhan
dc.date.accessioned2024-07-19T13:50:50Z
dc.date.available2024-07-19T13:50:50Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionThis study was supported by the Bolu Abant & Idot;zzet Baysal University Fund.en_US
dc.description.abstractOBJECTIVES: The aim of the study is to investigate the effects of Protocatechuic Acid (PCA), which is an antioxidant, anti-inflammatory and anti-apoptotic agent, on ovarian tissue and ovarian reserve against ischemia-reperfusion (IR) injury in a rat ovarian torsion model.BACKGROUND: Reactive oxygen radicals cause histopathological changes in the ovarian tissue during the reperfusion phase. PCA may have protective effects on ovarian tissue and reserve due to its antioxidant and antiapoptotic properties.METHODS: A total of 24 Wistar adult female rats were divided into 3 groups as the control (sham operation, n = 8), IR (Ischemia-Reperfusion, n = 8), and IR+PCA (Ischemia-Reperfusion + 80 mg/kg protocatechuic acid, n = 8). The IR and IR + PCA groups underwent 3 hours of ischemia followed by 3 hours of ovarian reperfusion. Protocatechuic acid (80 mg/kg) was administered to the IR+PCA group 30 minutes before reperfusion. After reperfusion, the ovaries were removed for histopathological and biochemical examination.RESULTS: Histopathological score and TUNEL+ cell count were significantly lower and AMH expression level was significantly higher in the IR+PCA group when compared to the IR group (p <0.05). However, in the comparison of the follicle counts, there was no statistically signifi cant difference between all groups. Due to the increase in antioxidant activity, the MDA levels were found to be significantly lower in the IR+PCA group compared to the IR group (p < 0.05).CONCLUSION: Protocatechuic acid may be an effective antioxidant in protecting ovarian tissue and follicle reserve against IR injury of the ovary (Tab. 1, Fig. 4, Ref. 36). T ext in PDF www.elis.sken_US
dc.description.sponsorshipBolu Abant Idot;zzet Baysal University Funden_US
dc.identifier.citationErimsah, S., & Cetinkaya, A. (2023). The effect of protocatechuic acid on ovarian histopathology and reserve in rat ovarian torsion model. Bratislava Medical Journal/Bratislavské Lekárske Listy, 124(11).en_US
dc.identifier.doi10.4149/BLL_2023_129
dc.identifier.endpage847en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue11en_US
dc.identifier.pmid37874807en_US
dc.identifier.scopus2-s2.0-85175741346en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage842en_US
dc.identifier.urihttp://dx.doi.org/10.4149/BLL_2023_129
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12256
dc.identifier.volume124en_US
dc.identifier.wosWOS:001100699100008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇetinkaya, yhan
dc.language.isoenen_US
dc.publisherAEPRESS SROen_US
dc.relation.ispartofBratislava Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProtocatechuic Aciden_US
dc.subjectIschemia Reperfusionen_US
dc.subjectDetorsionen_US
dc.subjectAdnexal Torsionen_US
dc.subjectHormone-Levelsen_US
dc.subjectDetorsionen_US
dc.titleThe effect of protocatechuic acid on ovarian histopathology and reserve in rat ovarian torsion modelen_US
dc.typeArticleen_US

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