Efficacy of intraarticular application of ketamine or ketamine-levobupivacaine combination on post-operative pain after arthroscopic meniscectomy

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dc.authorid0000-0003-2221-4731en_US
dc.authorid0000-0002-9750-9350
dc.authorid0000-0003-4139-5080
dc.contributor.authorIşık, Cengiz
dc.contributor.authorDemirhan, Abdullah
dc.contributor.authorYetiş, Tevfik
dc.contributor.authorÖktem, Korgun
dc.contributor.authorSarman, Hakan
dc.contributor.authorTekelioğlu, Ümit Yaşar
dc.contributor.authorDuran, Turan
dc.date.accessioned2021-06-23T19:41:55Z
dc.date.available2021-06-23T19:41:55Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractTo evaluate the efficacy of intraarticular injection of ketamine or ketamine plus levobupivacaine on post-operative analgesia in patients undergoing arthroscopic meniscectomy. A prospective, randomized, double-blind study was performed on 60 patients aged 18-65 years who planned to undergo elective arthroscopic meniscectomy. The patients were divided into three groups: the ketamine group (n = 20) received 1.0 mg/kg of intraarticular ketamine in 20 ml of normal saline, the ketamine-levobupivacaine group (n = 20) received 0.5 mg/kg of intraarticular ketamine plus 50.0 mg of 0.25 % levobupivacaine in 20 ml of normal saline, and the control group (n = 20) received 20 ml of intraarticular normal saline. A visual analogue scale (VAS) was used to determine the efficacy of analgesia at 1, 2, 4, 6, 8, 12, and 24 h post-operatively. There were statistically significant differences in the median VAS scores among the three groups according to Bonferroni adjustment at all time points (p < 0.01), with the exception of 6 and 24 h post-operatively. The median VAS scores at 1, 2, and 4 h post-operatively were higher in the control group than in the two treatment groups (p < 0.001). The median VAS scores in the control group at 1, 2, 4, 6, 8, and 12 h post-operatively and those in the ketamine group at 4, 8, and 12 h post-operatively were significantly higher than those in the ketamine-levobupivacaine group (p < 0.05). Intraarticular ketamine provides effective post-operative analgesia. Addition of intraarticular levobupivacaine to ketamine may provide better amelioration of pain after outpatient arthroscopic meniscectomy. I.en_US
dc.identifier.doi10.1007/s00167-014-2962-0
dc.identifier.endpage2726en_US
dc.identifier.issn0942-2056
dc.identifier.issn1433-7347
dc.identifier.issue9en_US
dc.identifier.pmid24671388en_US
dc.identifier.scopus2-s2.0-84939569413en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2721en_US
dc.identifier.urihttps://doi.org/10.1007/s00167-014-2962-0
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8229
dc.identifier.volume23en_US
dc.identifier.wosWOS:000360003300039en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorIşık, Cengiz
dc.institutionauthorDemirhan, Abdullah
dc.institutionauthorSarman, Hakan
dc.institutionauthorTekelioğlu, Ümit Yaşar
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofKnee Surgery Sports Traumatology Arthroscopyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArthroscopic Meniscectomyen_US
dc.subjectIntraarticular Injectionen_US
dc.subjectKetamineen_US
dc.subjectLevobupivacaineen_US
dc.titleEfficacy of intraarticular application of ketamine or ketamine-levobupivacaine combination on post-operative pain after arthroscopic meniscectomyen_US
dc.typeArticleen_US

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